Abstract：
Carbon monoxide (CO) poisoning is the leading cause of poisoning-related deaths globally. The currently available therapy options are normobaric oxygen (NBO) and hyperbaric oxygen (HBO). While NBO lacks in efficacy, HBO is not available in all areas and countries. We present a novel method, extracorporeal hyperoxygenation therapy (EHT), for the treatment of CO poisoning that eliminates the CO by treating blood extracorporeally at elevated oxygen partial pressure. In this study, we proof the principle of the method in vitro using procine blood: Firstly, we investigated the difference in the CO elimination of a hollow fibre membrane oxygenator and a specifically designed batch oxygenator based on the bubble oxygenator principle at elevated pressures (1, 3 bar). Secondly, the batch oxygenator was redesigned and tested for a broader range of pressures (1, 3, 5, 7 bar) and temperatures (23, 30, 37 °C). So far, the shortest measured carboxyhemoglobin half-life in the blood was 21.32 min. In conclusion, EHT has the potential to provide an easily available and effective method for the treatment of CO poisoning.
摘要：
一氧化碳（CO）中毒是全球中毒相关死亡的主要原因。目前可用的治疗选择是常压氧(NBO)和高压氧(HBO)。虽然NBO缺乏功效，HBO并非在所有地区和国家都可用。我们提出了一种新的方法，体外高氧合治疗（EHT），用于治疗CO中毒，通过在升高的氧分压下对血液进行体外治疗来消除CO。在这项研究中,我们证明了该方法在体外使用普星血液的原理：首先，我们研究了中空纤维膜充氧器和基于气泡充氧器原理在高压（1,3bar）下专门设计的间歇式充氧器的CO消除差异。其次,重新设计了批量充氧器，并在更宽的压力（1、3、5、7bar）和温度（23、30、37°C）范围内进行了测试。到目前为止,在血液中测量到的最短的碳氧血红蛋白半衰期为21.32min.总之,EHT有可能为CO中毒的治疗提供一种简便有效的方法。
