Abstract：
BACKGROUND: Vitamin K-dependent proteins (VKDPs) and the epidermal growth factor receptor (EGFR) are involved in lung cancer progression. Therefore, we aimed to study the serum concentration of Matrix Gla protein (MGP), Growth Arrest-specific 6 (Gas6), and EGFR before and after the first cycle of chemotherapy and to investigate how MGP, Gas6, and EGFR are modified after one cycle of chemotherapy.
METHODS: We performed an observational study on twenty patients diagnosed with lung cancer, by assessing the serum concentration of vitaminK1 (VitK1), MGP, Gas6, and EGFR using the ELISA technique before and after three weeks of the first cycle of chemotherapy. Patients were evaluated using RECIST 1.1 criteria.
RESULTS: Serum levels of MGP, Gas6, EGFR, and VK1 before and after treatment were not changed significantly. Regarding the pre-treatment correlation of the MGP values, we found a strong positive relationship between MGP and VK1 pre-treatment values (r = 0.821, 95%CI 0.523; 0.954, p < 0.001). Furthermore, there was a moderately negative correlation between VK1 and EGFR pre-treatment values, with the relationship between them being marginally significant (r = -0.430, 95%CI -0.772; 0.001, p = 0.058). Post-treatment, we found a strong positive relationship between MGP and VK1 post-treatment values (r = 0.758, 95%CI 0.436; 0.900, p < 0.001). We also found a moderate positive relationship between Gas6 and EGFR post-treatment values, but the correlation was only marginally significant (r = 0.442, p = 0.051).
METHODS: We performed an observational study on twenty patients diagnosed with lung cancer, by assessing the serum concentration of vitaminK1 (VitK1), MGP, Gas6, and EGFR using the ELISA technique before and after three weeks of the first cycle of chemotherapy. Patients were evaluated using RECIST 1.1 criteria.
RESULTS: Serum levels of MGP, Gas6, EGFR, and VK1 before and after treatment were not changed significantly. Regarding the pre-treatment correlation of the MGP values, we found a strong positive relationship between MGP and VK1 pre-treatment values (r = 0.821, 95%CI 0.523; 0.954, p < 0.001). Furthermore, there was a moderately negative correlation between VK1 and EGFR pre-treatment values, with the relationship between them being marginally significant (r = -0.430, 95%CI -0.772; 0.001, p = 0.058). Post-treatment, we found a strong positive relationship between MGP and VK1 post-treatment values (r = 0.758, 95%CI 0.436; 0.900, p < 0.001). We also found a moderate positive relationship between Gas6 and EGFR post-treatment values, but the correlation was only marginally significant (r = 0.442, p = 0.051).
摘要：
背景：维生素K依赖性蛋白（VKDP）和表皮生长因子受体（EGFR）参与肺癌的进展。因此,我们旨在研究基质Gla蛋白（MGP）的血清浓度，特定增长逮捕6（Gas6），和EGFR在化疗前和后的第一个周期和探讨MGP,Gas6和EGFR在化疗一个周期后被修饰。
方法：我们对20例诊断为肺癌的患者进行了观察性研究，通过评估维生素K1（VitK1）的血清浓度，MGP,Gas6，和EGFR运用ELISA技巧在第1周期化疗前后三周。使用RECIST1.1标准对患者进行评估。
结果：血清MGP水平，Gas6,EGFR,治疗前后VK1无明显变化。关于MGP值的治疗前相关性，我们发现MGP和VK1治疗前值之间有很强的正相关关系(r=0.821,95CI0.523;0.954,p<0.001)。此外，VK1和EGFR治疗前值呈中度负相关，它们之间的关系略显着(r=-0.430，95CI-0.772；0.001，p=0.058)。后处理,我们发现MGP和治疗后VK1值之间存在强烈的正相关关系(r=0.758,95CI0.436;0.900,p<0.001)。我们还发现Gas6和EGFR治疗后值之间存在中度正相关关系，但相关性仅有轻微显著性(r=0.442,p=0.051)。
方法：我们对20例诊断为肺癌的患者进行了观察性研究，通过评估维生素K1（VitK1）的血清浓度，MGP,Gas6，和EGFR运用ELISA技巧在第1周期化疗前后三周。使用RECIST1.1标准对患者进行评估。
结果：血清MGP水平，Gas6,EGFR,治疗前后VK1无明显变化。关于MGP值的治疗前相关性，我们发现MGP和VK1治疗前值之间有很强的正相关关系(r=0.821,95CI0.523;0.954,p<0.001)。此外，VK1和EGFR治疗前值呈中度负相关，它们之间的关系略显着(r=-0.430，95CI-0.772；0.001，p=0.058)。后处理,我们发现MGP和治疗后VK1值之间存在强烈的正相关关系(r=0.758,95CI0.436;0.900,p<0.001)。我们还发现Gas6和EGFR治疗后值之间存在中度正相关关系，但相关性仅有轻微显著性(r=0.442,p=0.051)。
