PDF(Pubmed)
Abstract：
The proper development and the homeostasis maintenance of bones are important prerequisites for the normal functioning of the human body. Bone developmental deformities or homeostasis disorders, such as Kashin-Beck disease, craniosynostosis, cleft palate and osteoarthritis, severely affect the life of patients, causing significant stress to the family and the society. Fibroblast growth factor 8 (FGF8) plays multiple functions through the course of the life of organisms. Abnormal expression of FGF8 may cause disorders of bone homeostasis and developmental abnormalities of bones. More and more studies have found that FGF8 may play an important role in bone development and may become a potential therapeutic target. Herein, we reviewed the role of FGF8 in a variety of skeletal abnormalities, intending to provide new perspectives for the prevention and treatment of related diseases in the future.
摘要：
骨骼的适当发育和稳态维持是人体正常功能的重要先决条件。骨发育畸形或体内平衡障碍，比如大骨节病,颅骨融合症,腭裂和骨关节炎，严重影响患者的生活，给家庭和社会造成巨大压力。成纤维细胞生长因子8(FGF8)在生物体的生命过程中发挥多种功能。FGF8的异常表达可能导致骨稳态紊乱和骨发育异常。越来越多的研究发现FGF8可能在骨骼发育中发挥重要作用,并可能成为潜在的治疗靶点。在这里，我们回顾了FGF8在多种骨骼异常中的作用，旨在为今后相关疾病的预防和治疗提供新的视角。
