PDF(Pubmed)
Abstract：
Background and aims: Periodontitis is an inflammatory-infectious disease. Identifying markers of systemic exposure of periodontitis might be of interest to study its interaction with other conditions. Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) is upregulated during bacterial infections. Our aim was therefore to investigate whether periodontitis and its treatment are associated with bacterial endotoxin and sTREM-1. Methods: Fifty patients with severe periodontitis and 50 age-matched controls were included in a case-control study (all never smokers). A secondary analysis of a previously published intervention study was performed, in which included 69 patients with severe periodontitis were randomized to receive either intensive (IPT) or control periodontal therapy (CPT) and monitored over 6 months. Serum levels of bacterial endotoxin and sTREM-1 were determined at one time point (case-control study) and at baseline, 1 day, 1 and 6 months after periodontal treatment (intervention study). Results: Severe periodontitis was associated with elevated circulating endotoxin levels when cases (22.9 ± 2.2 EU/ml) were compared to controls (3.6 ± 0.5 EU/ml, p < 0.001) and with sTREM-1 levels (1302.6 ± 47.8 vs. 870.6 ± 62.0 pg/ml, p < 0.001). A positive correlation was observed between sTREM-1 and endotoxin levels (r = 0.4, p < 0.001). At 6 months after treatment, IPT significantly decreased serum levels of sTREM-1 compared to CPT (adjusted mean difference of 500.2 pg/ml, 95% CI: 18.9-981.4; p = 0.042). No substantial differences were noted in endotoxin levels at any time point after treatment between groups. Conclusions: Severe periodontitis is linked to increased circulating endotoxin and sTREM-1 levels and following IPT a reduction in sTREM-1 levels is observed.
摘要：
背景和目的：牙周炎是一种炎症性传染病。鉴定牙周炎全身暴露的标志物可能对研究其与其他条件的相互作用感兴趣。在骨髓细胞1上表达的可溶性触发受体(sTREM-1)在细菌感染期间上调。因此，我们的目的是研究牙周炎及其治疗是否与细菌内毒素和sTREM-1有关。方法：将50例重度牙周炎患者和50例年龄匹配的对照者纳入病例对照研究（均从不吸烟者）。对先前发表的干预研究进行了二次分析，其中包括69例重度牙周炎患者被随机分配接受强化(IPT)或对照牙周治疗(CPT),并监测6个月.在一个时间点（病例对照研究）和基线时测定血清细菌内毒素和sTREM-1水平，1天,牙周医治后1个月和6个月（干涉研讨）。结果：当病例（22.9±2.2EU/ml）与对照组（3.6±0.5EU/ml，p<0.001）和sTREM-1水平（1302.6±47.8vs.870.6±62.0pg/ml，p<0.001)。sTREM-1与内毒素水平呈正相关(r=0.4,p<0.001)。治疗后6个月，与CPT相比，IPT显着降低sTREM-1的血清水平（调整后的平均差为500.2pg/ml，95%CI：18.9-981.4；p=0.042）。在治疗后的任何时间点，各组之间的内毒素水平均无实质性差异。结论：严重牙周炎与循环内毒素和sTREM-1水平升高有关，IPT后观察到sTREM-1水平降低。
