OBJECTIVE: Investigate whether admission serum Hp and glutamic dehydrogenase (GLDH) are associated with systemic inflammatory response syndrome (SIRS) and survival of sick calves.
METHODS: One hundred two calves.
METHODS: Retrospective cross-sectional study. Electronic medical records from all calves <30 days of age admitted to a teaching hospital for 8 years were reviewed. The signalment, clinicopathological findings, the presence of SIRS, final diagnosis, hospitalization time and outcome were recorded. A Cox proportional hazard ratio (HzR) were calculated to assess the association between clinicopathological variables and survival to discharge.
RESULTS: Serum Hp concentrations were similar between SIRS (0.29 g/L; range, 0.05-3.6) and non-SIRS calves (0.22 g/L; range, 0-4.2; P = .62). GLDH activity was similar between SIRS (12 U/L; range, 1-1025) and non-SIRS calves (9 U/L; range, 2-137; P = .2). Absent suckle reflex (HzR: 6.44, 95% CI: 1.44-28.86), heart rate (HR) < 100 beats per minute (bpm; HzR: 12.2; 95% CI: 2.54-58.62), HR > 140 bpm (HzR: 3.59, 95% CI: 1.05-12.33), neutrophil count <1.7 × 109 /L (HzR: 7.36; 95% CI: 2.03-26.66) and increased gamma-glutamyl transferase activity (every 50-unit, HzR: 1.12; 95% CI: 1.03-1.21) were predictive of nonsurvival.
CONCLUSIONS: The use of Hp and GLDH for prediction of survival in sick calves cannot be recommended at this time.
目的:研究入院血清Hp和谷氨酸脱氢酶(GLDH)是否与全身炎症反应综合征(SIRS)和病牛的生存有关。
方法:一百二头小牛。
方法:回顾性横断面研究。回顾了所有年龄<30天的小牛在教学医院接受了8年的电子病历。标志,临床病理发现,SIRS的存在,最终诊断,记录住院时间和结果.计算Cox比例风险比(HzR)以评估临床病理变量与出院生存率之间的关联。
结果:SIRS之间的血清Hp浓度相似(0.29g/L;范围,0.05-3.6)和非SIRS小牛(0.22g/L;范围,0-4.2;P=.62)。SIRS之间的GLDH活性相似(12U/L;范围,1-1025)和非SIRS小牛(9U/L;范围,2-137;P=.2)。缺乏屈膝反射(HzR:6.44,95%CI:1.44-28.86),心率(HR)<100次/分钟(bpm;HzR:12.2;95%CI:2.54-58.62),HR>140bpm(HzR:3.59,95%CI:1.05-12.33),中性粒细胞计数<1.7×109/L(HzR:7.36;95%CI:2.03-26.66)和增加的γ-谷氨酰转移酶活性(每50单位,HzR:1.12;95%CI:1.03-1.21)是无生存的预测指标。
结论:目前不推荐使用Hp和GLDH预测病牛的存活。