Abstract：
BACKGROUND: Increased concentration of haptoglobin (Hp) in serum is associated with survival of critically ill humans and horses. High serum activity of liver-derived enzyme is associated with sepsis in children and foals.
OBJECTIVE: Investigate whether admission serum Hp and glutamic dehydrogenase (GLDH) are associated with systemic inflammatory response syndrome (SIRS) and survival of sick calves.
METHODS: One hundred two calves.
METHODS: Retrospective cross-sectional study. Electronic medical records from all calves <30 days of age admitted to a teaching hospital for 8 years were reviewed. The signalment, clinicopathological findings, the presence of SIRS, final diagnosis, hospitalization time and outcome were recorded. A Cox proportional hazard ratio (HzR) were calculated to assess the association between clinicopathological variables and survival to discharge.
RESULTS: Serum Hp concentrations were similar between SIRS (0.29 g/L; range, 0.05-3.6) and non-SIRS calves (0.22 g/L; range, 0-4.2; P = .62). GLDH activity was similar between SIRS (12 U/L; range, 1-1025) and non-SIRS calves (9 U/L; range, 2-137; P = .2). Absent suckle reflex (HzR: 6.44, 95% CI: 1.44-28.86), heart rate (HR) < 100 beats per minute (bpm; HzR: 12.2; 95% CI: 2.54-58.62), HR > 140 bpm (HzR: 3.59, 95% CI: 1.05-12.33), neutrophil count <1.7 × 109 /L (HzR: 7.36; 95% CI: 2.03-26.66) and increased gamma-glutamyl transferase activity (every 50-unit, HzR: 1.12; 95% CI: 1.03-1.21) were predictive of nonsurvival.
CONCLUSIONS: The use of Hp and GLDH for prediction of survival in sick calves cannot be recommended at this time.
OBJECTIVE: Investigate whether admission serum Hp and glutamic dehydrogenase (GLDH) are associated with systemic inflammatory response syndrome (SIRS) and survival of sick calves.
METHODS: One hundred two calves.
METHODS: Retrospective cross-sectional study. Electronic medical records from all calves <30 days of age admitted to a teaching hospital for 8 years were reviewed. The signalment, clinicopathological findings, the presence of SIRS, final diagnosis, hospitalization time and outcome were recorded. A Cox proportional hazard ratio (HzR) were calculated to assess the association between clinicopathological variables and survival to discharge.
RESULTS: Serum Hp concentrations were similar between SIRS (0.29 g/L; range, 0.05-3.6) and non-SIRS calves (0.22 g/L; range, 0-4.2; P = .62). GLDH activity was similar between SIRS (12 U/L; range, 1-1025) and non-SIRS calves (9 U/L; range, 2-137; P = .2). Absent suckle reflex (HzR: 6.44, 95% CI: 1.44-28.86), heart rate (HR) < 100 beats per minute (bpm; HzR: 12.2; 95% CI: 2.54-58.62), HR > 140 bpm (HzR: 3.59, 95% CI: 1.05-12.33), neutrophil count <1.7 × 109 /L (HzR: 7.36; 95% CI: 2.03-26.66) and increased gamma-glutamyl transferase activity (every 50-unit, HzR: 1.12; 95% CI: 1.03-1.21) were predictive of nonsurvival.
CONCLUSIONS: The use of Hp and GLDH for prediction of survival in sick calves cannot be recommended at this time.
摘要：
背景:血清中触珠蛋白(Hp)浓度的增加与危重病人和马的存活相关。肝脏衍生酶的高血清活性与儿童和小马驹的败血症有关。
目的：研究入院血清Hp和谷氨酸脱氢酶（GLDH）是否与全身炎症反应综合征（SIRS）和病牛的生存有关。
方法：一百二头小牛。
方法：回顾性横断面研究。回顾了所有年龄<30天的小牛在教学医院接受了8年的电子病历。标志，临床病理发现，SIRS的存在，最终诊断,记录住院时间和结果.计算Cox比例风险比（HzR）以评估临床病理变量与出院生存率之间的关联。
结果：SIRS之间的血清Hp浓度相似（0.29g/L；范围，0.05-3.6）和非SIRS小牛（0.22g/L；范围，0-4.2；P=.62）。SIRS之间的GLDH活性相似（12U/L；范围，1-1025）和非SIRS小牛（9U/L；范围，2-137；P=.2）。缺乏屈膝反射（HzR：6.44，95%CI：1.44-28.86），心率（HR）<100次/分钟（bpm;HzR：12.2;95％CI：2.54-58.62），HR>140bpm（HzR：3.59，95%CI：1.05-12.33），中性粒细胞计数<1.7×109/L（HzR：7.36;95％CI：2.03-26.66）和增加的γ-谷氨酰转移酶活性（每50单位，HzR：1.12；95%CI：1.03-1.21)是无生存的预测指标。
结论：目前不推荐使用Hp和GLDH预测病牛的存活。
目的：研究入院血清Hp和谷氨酸脱氢酶（GLDH）是否与全身炎症反应综合征（SIRS）和病牛的生存有关。
方法：一百二头小牛。
方法：回顾性横断面研究。回顾了所有年龄<30天的小牛在教学医院接受了8年的电子病历。标志，临床病理发现，SIRS的存在，最终诊断,记录住院时间和结果.计算Cox比例风险比（HzR）以评估临床病理变量与出院生存率之间的关联。
结果：SIRS之间的血清Hp浓度相似（0.29g/L；范围，0.05-3.6）和非SIRS小牛（0.22g/L；范围，0-4.2；P=.62）。SIRS之间的GLDH活性相似（12U/L；范围，1-1025）和非SIRS小牛（9U/L；范围，2-137；P=.2）。缺乏屈膝反射（HzR：6.44，95%CI：1.44-28.86），心率（HR）<100次/分钟（bpm;HzR：12.2;95％CI：2.54-58.62），HR>140bpm（HzR：3.59，95%CI：1.05-12.33），中性粒细胞计数<1.7×109/L（HzR：7.36;95％CI：2.03-26.66）和增加的γ-谷氨酰转移酶活性（每50单位，HzR：1.12；95%CI：1.03-1.21)是无生存的预测指标。
结论：目前不推荐使用Hp和GLDH预测病牛的存活。
