Abstract：
BACKGROUND: Previous reports have described hypogonadism associated with virus infection such as hantavirus, human immunodeficiency virus (HIV) or severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). However, to our best knowledge there has been no case report of secondary hypogonadism following hand, foot, and mouth disease (HFMD).
METHODS: A previously healthy 28-year-old man with no history of major physical and psychological trauma, presented with bilateral gynecomastia and erectile dysfunction 2 weeks after HFMD. Laboratory testament showed the level of gonadotropin hormones declined. Imaging examination demonstrated no major abnormal change in pituitary or reproductive system. The diagnosis of hypogonadism was established. Then the patient was ordered to maintain mental health outward of hospital without drug intervention. One month after presentation, his gonadotropin hormone level and sexual desire had recovered, while bilateral gynecomastia and erectile dysfunction symptoms disappeared.
CONCLUSIONS: Physicians should notice the possibility for hypogonadism in adult patients with a recent history of HFMD.
METHODS: A previously healthy 28-year-old man with no history of major physical and psychological trauma, presented with bilateral gynecomastia and erectile dysfunction 2 weeks after HFMD. Laboratory testament showed the level of gonadotropin hormones declined. Imaging examination demonstrated no major abnormal change in pituitary or reproductive system. The diagnosis of hypogonadism was established. Then the patient was ordered to maintain mental health outward of hospital without drug intervention. One month after presentation, his gonadotropin hormone level and sexual desire had recovered, while bilateral gynecomastia and erectile dysfunction symptoms disappeared.
CONCLUSIONS: Physicians should notice the possibility for hypogonadism in adult patients with a recent history of HFMD.
摘要：
背景：以前的报道描述了与汉坦病毒等病毒感染相关的性腺机能减退，人类免疫缺陷病毒（HIV）或严重急性呼吸道综合症冠状病毒2（SARS-COV-2）。然而,据我们所知，没有继发性腺机能减退的病例报告，脚,和口蹄疫（HFMD）。
方法：一个以前健康的28岁男性，没有重大身体和心理创伤史，手足口病后2周出现双侧男性乳房发育和勃起功能障碍。实验室证明显示促性腺激素水平下降。影像学检查显示垂体或生殖系统无重大异常改变。确定了性腺机能减退的诊断。然后患者被命令在不进行药物干预的情况下保持医院外的心理健康。陈述后一个月，他的促性腺激素激素水平和性欲已经恢复，而双侧男性乳房发育和勃起功能障碍症状消失。
结论：医师应注意近期有HFMD病史的成年患者的性腺功能减退的可能性。
方法：一个以前健康的28岁男性，没有重大身体和心理创伤史，手足口病后2周出现双侧男性乳房发育和勃起功能障碍。实验室证明显示促性腺激素水平下降。影像学检查显示垂体或生殖系统无重大异常改变。确定了性腺机能减退的诊断。然后患者被命令在不进行药物干预的情况下保持医院外的心理健康。陈述后一个月，他的促性腺激素激素水平和性欲已经恢复，而双侧男性乳房发育和勃起功能障碍症状消失。
结论：医师应注意近期有HFMD病史的成年患者的性腺功能减退的可能性。
