Abstract：
Flavonoids are an important class of natural polyphenolic compounds reported to exert beneficial effects in cardiovascular and metabolic diseases, cancer, autoimmune and neurological disorders. Flavonoids possess potential antioxidant, anti-inflammatory, antiapoptotic and immuno-modulation properties. Intriguingly, the importance of flavonoids in different neurological disorders is gaining more attention due to the safety, better pharmacokinetic profile and blood-brain barrier penetration, cost-effectiveness and readiness for clinical uses/trials. Many in vitro and in vivo research studies have established the neuroprotective mechanism of flavonoids in the central nervous system (CNS) diseases. The present review summarizes the benefits of various classes of flavonoids (flavones, flavonols, flavanones, anthocyanidins, isoflavones, flavanols), chemical nature, classification, their occurrence and distribution, pharmacokinetics and bioavailability. The manuscript also presents available evidences relating to the role of flavonoids in regulating key signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway, mitogen-activated protein kinase (MAPK) pathway, Janus kinase and signal transducer and activator of transcription proteins (JAK/STAT) pathway, Toll-like receptors (TLR) pathway, nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and cAMP response element-binding protein (CREB) pathway involved in neuroinflammation associated with major neurological disorders. Literature search was conducted using electronic databases like Google Scholar, Scopus, PubMed central, Springer search and Web of science. Chemical structures used in the present analysis were drawn using Chemdraw Professional 15.0 software. This collective information provides comprehensive knowledge on disease pathways and therapeutic benefits of flavonoids in neurological disorders, druggability and future scope for research.
摘要：
黄酮类化合物是一类重要的天然多酚化合物，据报道在心血管和代谢性疾病中发挥有益作用。癌症,自身免疫性和神经系统疾病。黄酮类化合物具有潜在的抗氧化剂，抗炎,抗凋亡和免疫调节特性。有趣的是，黄酮类化合物在不同神经系统疾病中的重要性因其安全性而受到更多关注,更好的药代动力学特征和血脑屏障渗透，成本效益和临床使用/试验的准备。许多体外和体内研究已经建立了黄酮类化合物在中枢神经系统（CNS）疾病中的神经保护机制。本综述总结了各种类黄酮(黄酮，黄酮醇，黄烷酮,花青素,异黄酮,黄烷醇)，化学性质,分类，它们的发生和分布，药代动力学和生物利用度。手稿还提供了有关黄酮类化合物在调节关键信号通路中的作用的可用证据，例如活化B细胞的核因子κ-轻链增强子（NF-κB）通路，丝裂原活化蛋白激酶(MAPK)途径,Janus激酶和信号转导和转录激活蛋白（JAK/STAT）途径，Toll样受体（TLR）途径，核因子红系2相关因子2（Nrf2）通路和cAMP反应元件结合蛋白（CREB）通路参与与主要神经系统疾病相关的神经炎症。文献检索是使用像谷歌学者这样的电子数据库进行的，Scopus,PubMed中央,斯普林格搜索和WebofScience。使用ChemdrawProfessional15.0软件绘制本分析中使用的化学结构。这些集体信息提供了有关神经系统疾病中黄酮类化合物的疾病途径和治疗益处的全面知识，可药用性和未来的研究范围。
