蛋白质组学和代谢表型确定了小鼠肝脏中芳烃受体的主要作用。
关键词: AHR AHR, aryl hydrocarbon receptor ALT, alanine transaminase ANOVA, analysis of variance AST, aspartate transaminase AUC, area under the curve CAR, constitutive androstane receptor CD36, cluster of differentiation 36 CYP, cytochrome P450 EPF, enrichment by protein function Endocrine disruption Environmental liver disease FDR, false discovery rate FGF21, fibroblast growth factor 21 GCR, glucocorticoid receptor GO, gene ontology H&E, hematoxylin-eosin HDL, high-density lipoprotein HFD, high fat diet IGF1, insulin-like growth factor 1 IL-6, interleukin 6 IPF, interaction by protein function LDL, low-density lipoprotein MCP-1, monocyte chemoattractant protein-1 MUP, major urinary protein NAFLD, non-alcoholic fatty liver disease NFKBIA, nuclear factor kappa-inhibitor alpha Nonalcoholic fatty liver disease PAI-1, plasminogen activator inhibitor-1 PCB, polychlorinated biphenyl PCB126 PLIN2, perilipin-2 PNPLA3, patatin-like phospholipase domain-containing protein 3 PPARα, peroxisome proliferator-activated receptor alpha PXR, pregnane-xenobiotic receptor Perilipin-2 Pheromones SGK1, serum/glucocorticoid regulated kinase TAFLD, toxicant-associated fatty liver disease TASH, toxicant-associated steatohepatitis TAT, tyrosine aminotransferase TMT, tandem mass tag VLDL, very low-density lipoprotein WT, wild type ZFP125, zinc finger protein 125 miR, microRNA nHDLc, non-HDL cholesterol
来 源:
DOI:10.1016/j.apsb.2021.10.014
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