PDF(Pubmed)
Abstract：
OBJECTIVE: Although multiple mechanisms associated with Peyronie\'s disease (PD) have been proposed, details regarding etiologic factors, especially genetic, remain unclear. We examined the relationship of the ABO blood type system, known as a genetic factor associated with susceptibility to a number of diseases, with PD in Japanese males.
METHODS: We compared 202 Japanese PD patients treated with surgery at our hospital between March 2004 and December 2019 with 846 randomly selected non-PD male patients who underwent urological surgery during the same period regarding distribution of ABO blood types. In addition, we assessed the risk of PD according to blood type group among all study participants using odds ratio (OR) and 95% confidence interval (CI) calculations.
RESULTS: The distribution of individual blood types in the control group was nearly the same as that in the general Japanese population. In contrast, O, A, B, and AB blood types were noted in 37.6%, 36.1%, 14.9% and 11.4%, respectively, of the PD patients, which was significantly different from the control group, where blood type O was found in 29.1% and B in 23.2% (p<0.05). Our results showed that as compared with patients with blood group B, those with another blood type were more likely to develop PD, among which type O had a significantly increased OR of 2.018 (CI, 1.271-3.205).
CONCLUSIONS: These are the first reported results showing that ABO blood type may be associated with risk of PD, though further investigations are needed.
METHODS: We compared 202 Japanese PD patients treated with surgery at our hospital between March 2004 and December 2019 with 846 randomly selected non-PD male patients who underwent urological surgery during the same period regarding distribution of ABO blood types. In addition, we assessed the risk of PD according to blood type group among all study participants using odds ratio (OR) and 95% confidence interval (CI) calculations.
RESULTS: The distribution of individual blood types in the control group was nearly the same as that in the general Japanese population. In contrast, O, A, B, and AB blood types were noted in 37.6%, 36.1%, 14.9% and 11.4%, respectively, of the PD patients, which was significantly different from the control group, where blood type O was found in 29.1% and B in 23.2% (p<0.05). Our results showed that as compared with patients with blood group B, those with another blood type were more likely to develop PD, among which type O had a significantly increased OR of 2.018 (CI, 1.271-3.205).
CONCLUSIONS: These are the first reported results showing that ABO blood type may be associated with risk of PD, though further investigations are needed.
摘要：
目的：尽管已经提出了与Peyronie病（PD）相关的多种机制，有关病因的详细信息，尤其是遗传,仍然不清楚。我们检查了ABO血型系统的关系，被称为与多种疾病易感性相关的遗传因素，日本男性的PD。
方法：我们比较了2004年3月至2019年12月在我院接受手术治疗的202例日本PD患者与同期接受泌尿外科手术的846例随机选择的非PD男性患者的ABO血型分布。此外,我们使用比值比(OR)和95%置信区间(CI)计算,根据血型在所有研究参与者中评估PD的风险.
结果：对照组的个体血型分布与一般日本人群几乎相同。相比之下,O,A,B,AB型血占37.6%,36.1%,14.9%和11.4%，分别,PD患者，这与对照组有显著差异，其中O型血占29.1%，B型血占23.2%(p<0.05)。我们的结果显示，与血型B的患者相比，另一种血型的人更有可能患上PD，其中O型的OR显著增加,为2.018(CI,1.271~3.205)。
结论：这些是首次报道的结果表明ABO血型可能与PD的风险有关，尽管需要进一步调查。
方法：我们比较了2004年3月至2019年12月在我院接受手术治疗的202例日本PD患者与同期接受泌尿外科手术的846例随机选择的非PD男性患者的ABO血型分布。此外,我们使用比值比(OR)和95%置信区间(CI)计算,根据血型在所有研究参与者中评估PD的风险.
结果：对照组的个体血型分布与一般日本人群几乎相同。相比之下,O,A,B,AB型血占37.6%,36.1%,14.9%和11.4%，分别,PD患者，这与对照组有显著差异，其中O型血占29.1%，B型血占23.2%(p<0.05)。我们的结果显示，与血型B的患者相比，另一种血型的人更有可能患上PD，其中O型的OR显著增加,为2.018(CI,1.271~3.205)。
结论：这些是首次报道的结果表明ABO血型可能与PD的风险有关，尽管需要进一步调查。
