Abstract：
OBJECTIVE: Antimicrobial resistance of nontyphoidal Salmonella (NTS) is a threat to public health worldwide.
METHODS: A study on longitudinally collected NTS isolates from a medical center in Taiwan from 2011 to 2019 was undertaken. The multidrug resistance (MDR) and extensively drug resistance (XDR) phenotypes were determined according to internationally used definitions. Molecular serotyping was performed on the resistant NTS.
RESULTS: Notably 16.1% (870/5412) of the isolates were MDR, while XDR accounted for 2.1% (111/5412). Both MDR and XDR NTS have increased significantly from 2011 to 2019, especially from 2015 to 2017 (MDR from 9.6% in 2015 to 23.1% 2017; XDR from 1.4% in 2016 to 4.7% in 2017). S. Anatum was the commonest NTS serotype expressing MDR and XDR, in 256/559 (45.8%) and 81/111 (73.0%) of the isolates, respectively, followed by S. Typhimurium and S. Goldcoast. Children < 18 years old contributed to 69.0% of all MDR cases and 64.0% of all XDR cases; majority of them aged less than 5 years.
CONCLUSIONS: Increasing MDR and XDR NTS is a threat to public health. MDR and XDR NTS usually caused gastroenteritis in children < 5 years old. Multiple NTS serotypes expressing MDR and XDR indicate multiple food vehicles involved in the transmission. Proper food hygiene practice should never be over-reinforced.
METHODS: A study on longitudinally collected NTS isolates from a medical center in Taiwan from 2011 to 2019 was undertaken. The multidrug resistance (MDR) and extensively drug resistance (XDR) phenotypes were determined according to internationally used definitions. Molecular serotyping was performed on the resistant NTS.
RESULTS: Notably 16.1% (870/5412) of the isolates were MDR, while XDR accounted for 2.1% (111/5412). Both MDR and XDR NTS have increased significantly from 2011 to 2019, especially from 2015 to 2017 (MDR from 9.6% in 2015 to 23.1% 2017; XDR from 1.4% in 2016 to 4.7% in 2017). S. Anatum was the commonest NTS serotype expressing MDR and XDR, in 256/559 (45.8%) and 81/111 (73.0%) of the isolates, respectively, followed by S. Typhimurium and S. Goldcoast. Children < 18 years old contributed to 69.0% of all MDR cases and 64.0% of all XDR cases; majority of them aged less than 5 years.
CONCLUSIONS: Increasing MDR and XDR NTS is a threat to public health. MDR and XDR NTS usually caused gastroenteritis in children < 5 years old. Multiple NTS serotypes expressing MDR and XDR indicate multiple food vehicles involved in the transmission. Proper food hygiene practice should never be over-reinforced.
摘要：
目的：非伤寒沙门氏菌（NTS）的耐药性是全球公共卫生的威胁。
方法：对2011年至2019年台湾某医疗中心纵向收集的NTS分离株进行了研究。根据国际上使用的定义确定了多药耐药（MDR）和广泛耐药（XDR）表型。对抗性NTS进行分子血清分型。
结果：值得注意的是，16.1％（870/5412）的分离株是MDR，XDR占2.1%(111/5412)。从2011年到2019年，MDR和XDRNTS均显着增加，特别是从2015年到2017年（MDR从2015年的9.6％增加到2017年的23.1％；XDR从2016年的1.4％增加到2017年的4.7％）。S.Anatum是表达MDR和XDR的最常见的NTS血清型，在256/559（45.8％）和81/111（73.0％）的分离物中，分别,其次是鼠伤寒沙门氏菌和Goldcoast沙门氏菌。<18岁的儿童占所有MDR病例的69.0％，占所有XDR病例的64.0％；其中大多数年龄小于5岁。
结论：增加MDR和XDRNTS是对公众健康的威胁。MDR和XDRNTS通常在<5岁的儿童中引起胃肠炎。表达MDR和XDR的多种NTS血清型表明参与传播的多种食物载体。正确的食品卫生实践绝不能过分加强。
方法：对2011年至2019年台湾某医疗中心纵向收集的NTS分离株进行了研究。根据国际上使用的定义确定了多药耐药（MDR）和广泛耐药（XDR）表型。对抗性NTS进行分子血清分型。
结果：值得注意的是，16.1％（870/5412）的分离株是MDR，XDR占2.1%(111/5412)。从2011年到2019年，MDR和XDRNTS均显着增加，特别是从2015年到2017年（MDR从2015年的9.6％增加到2017年的23.1％；XDR从2016年的1.4％增加到2017年的4.7％）。S.Anatum是表达MDR和XDR的最常见的NTS血清型，在256/559（45.8％）和81/111（73.0％）的分离物中，分别,其次是鼠伤寒沙门氏菌和Goldcoast沙门氏菌。<18岁的儿童占所有MDR病例的69.0％，占所有XDR病例的64.0％；其中大多数年龄小于5岁。
结论：增加MDR和XDRNTS是对公众健康的威胁。MDR和XDRNTS通常在<5岁的儿童中引起胃肠炎。表达MDR和XDR的多种NTS血清型表明参与传播的多种食物载体。正确的食品卫生实践绝不能过分加强。
