Abstract：
OBJECTIVE: This paper briefly reviews the pathological characteristics and regulatory mechanism of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome and summarizes the relationship between it and rheumatoid arthritis (RA) as a means to improve its therapeutic potential and clinical application.
BACKGROUND: RA is a systemic inflammatory disease with a high incidence rate. The early diagnosis and treatment of the disease is difficult, and the current treatment effect of most patients is not significant and accompanied by serious infection risk. Inflammation is an immune protective mechanism in the body. Inflammasome is an intracellular multi-body protein that stimulates the inflammatory response [inducing the release of pro-inflammatory cytokine interleukin (IL)-1β and IL-18] and promotes the death of thermophiles. The NLRP3 inflammatory bodies are assembled from NLRP3, apoptosis-associated speck-like protein (ASC), and pro-caspase-1. Previous studies have enriched our understanding of the activation mechanism of NLRP3 inflammasome, and animal model data suggests that it plays an important role in autoimmune diseases, including RA.
METHODS: Literatures about inflammation and RA were extensively reviewed to analyze and discuss.
CONCLUSIONS: Especially, we focused on the role of NLRP3 inflammasome in the pathogenesis of RA and the potential of NLRP3 inflammasome or their derivatives in the treatment of RA, which enriched the treatment strategies of inflammatory diseases.
BACKGROUND: RA is a systemic inflammatory disease with a high incidence rate. The early diagnosis and treatment of the disease is difficult, and the current treatment effect of most patients is not significant and accompanied by serious infection risk. Inflammation is an immune protective mechanism in the body. Inflammasome is an intracellular multi-body protein that stimulates the inflammatory response [inducing the release of pro-inflammatory cytokine interleukin (IL)-1β and IL-18] and promotes the death of thermophiles. The NLRP3 inflammatory bodies are assembled from NLRP3, apoptosis-associated speck-like protein (ASC), and pro-caspase-1. Previous studies have enriched our understanding of the activation mechanism of NLRP3 inflammasome, and animal model data suggests that it plays an important role in autoimmune diseases, including RA.
METHODS: Literatures about inflammation and RA were extensively reviewed to analyze and discuss.
CONCLUSIONS: Especially, we focused on the role of NLRP3 inflammasome in the pathogenesis of RA and the potential of NLRP3 inflammasome or their derivatives in the treatment of RA, which enriched the treatment strategies of inflammatory diseases.
摘要：
目的：本文简要综述了NOD样受体家族含pyrin结构域3(NLRP3)炎性体的病理特征和调控机制，并总结了其与类风湿关节炎(RA)的关系，以提高其治疗潜力和临床应用价值。
背景：RA是一种发病率较高的全身性炎症性疾病。该病的早期诊断和治疗是困难的,目前大多数患者的治疗效果并不显著，并伴有严重的感染风险。炎症是体内的免疫保护机制。炎症小体是一种细胞内多体蛋白，可刺激炎症反应[诱导促炎细胞因子白介素（IL）-1β和IL-18的释放]并促进嗜热菌的死亡。NLRP3炎性小体由NLRP3，凋亡相关斑点样蛋白（ASC）组装而成，和pro-caspase-1。以往的研究丰富了我们对NLRP3炎性体激活机制的认识,动物模型数据表明它在自身免疫性疾病中起着重要作用，包括RA。
方法：对炎症和类风湿性关节炎的相关文献进行广泛的回顾分析和讨论。
结论：特别是，我们关注NLRP3炎性体在RA发病中的作用以及NLRP3炎性体或其衍生物在治疗RA中的潜力,丰富了炎症性疾病的治疗策略。
背景：RA是一种发病率较高的全身性炎症性疾病。该病的早期诊断和治疗是困难的,目前大多数患者的治疗效果并不显著，并伴有严重的感染风险。炎症是体内的免疫保护机制。炎症小体是一种细胞内多体蛋白，可刺激炎症反应[诱导促炎细胞因子白介素（IL）-1β和IL-18的释放]并促进嗜热菌的死亡。NLRP3炎性小体由NLRP3，凋亡相关斑点样蛋白（ASC）组装而成，和pro-caspase-1。以往的研究丰富了我们对NLRP3炎性体激活机制的认识,动物模型数据表明它在自身免疫性疾病中起着重要作用，包括RA。
方法：对炎症和类风湿性关节炎的相关文献进行广泛的回顾分析和讨论。
结论：特别是，我们关注NLRP3炎性体在RA发病中的作用以及NLRP3炎性体或其衍生物在治疗RA中的潜力,丰富了炎症性疾病的治疗策略。
