Abstract：
Talaromyces Marneffei (Penicillium marneffei, T.marneffei) has been frequently reported in patients with adult acquired immunodeficiency syndrome. Still, cases of children with HIV combined with T.marneffei infection are very rare. This report describes the case of a HIV-child who is a girl from China. Her special clinical manifestations and laboratory diagnosis results can provide clinicians with the basis for diagnosis and treatment of T.marneffei related rare diseases.
We reported a single case of 7-year-old Chinese female patient who presented with fever, abdominal pain, multiple lymphadenopathy, hepatosplenomegaly, left lower extremity ecchymosis, and bloody stool. The patient received anti-inflammatory therapy; however, her symptoms did not improve. Consequently, she was diagnosed with T.marneffei and HIV infection; it was also confirmed that her mother did not undergo HIV blocking therapy during pregnancy. Yet, the child\'s family refused all treatment, after which the child was discharged from the hospital. The patient died a few days later.
This case suggested that children with AIDS suffering from fever, lymphadenopathy and coagulation dysfunction, penicilliosis should be suspected. Clinicians should diagnose the disease early through laboratory and imaging results, which can help reduce the mortality, prolong the survival time and improve the quality of life of children.
We reported a single case of 7-year-old Chinese female patient who presented with fever, abdominal pain, multiple lymphadenopathy, hepatosplenomegaly, left lower extremity ecchymosis, and bloody stool. The patient received anti-inflammatory therapy; however, her symptoms did not improve. Consequently, she was diagnosed with T.marneffei and HIV infection; it was also confirmed that her mother did not undergo HIV blocking therapy during pregnancy. Yet, the child\'s family refused all treatment, after which the child was discharged from the hospital. The patient died a few days later.
This case suggested that children with AIDS suffering from fever, lymphadenopathy and coagulation dysfunction, penicilliosis should be suspected. Clinicians should diagnose the disease early through laboratory and imaging results, which can help reduce the mortality, prolong the survival time and improve the quality of life of children.
摘要：
马尔尼菲塔拉酵母（马尔尼菲青霉菌，T.marneffei）在成人获得性免疫缺陷综合征患者中经常有报道。尽管如此，感染艾滋病毒的儿童合并马尔尼菲感染的病例非常罕见。本报告描述了一名来自中国的女孩感染艾滋病毒的情况。其特殊的临床表现和实验室诊断结果可为临床医生诊断和治疗马尔尼菲氏杆菌相关罕见病提供依据。
我们报告了一例7岁的中国女性患者出现发烧，腹痛,多发性淋巴结病,肝脾肿大,左下肢瘀斑,还有血淋淋的凳子.患者接受了抗炎治疗；然而，她的症状没有改善。因此,她被诊断出患有T.marneffei和HIV感染;还证实她的母亲在怀孕期间没有接受HIV阻断治疗。然而，孩子的家人拒绝了所有的治疗，之后孩子出院了。患者几天后死亡。
这个病例提示患有艾滋病的儿童发烧，淋巴结病和凝血功能障碍，应该怀疑青霉病。临床医生应通过实验室和影像学结果早期诊断疾病，这可以帮助降低死亡率，延长患儿的生存时间,提高患儿的生活质量。
我们报告了一例7岁的中国女性患者出现发烧，腹痛,多发性淋巴结病,肝脾肿大,左下肢瘀斑,还有血淋淋的凳子.患者接受了抗炎治疗；然而，她的症状没有改善。因此,她被诊断出患有T.marneffei和HIV感染;还证实她的母亲在怀孕期间没有接受HIV阻断治疗。然而，孩子的家人拒绝了所有的治疗，之后孩子出院了。患者几天后死亡。
这个病例提示患有艾滋病的儿童发烧，淋巴结病和凝血功能障碍，应该怀疑青霉病。临床医生应通过实验室和影像学结果早期诊断疾病，这可以帮助降低死亡率，延长患儿的生存时间,提高患儿的生活质量。
