关键词: Anti-GABAaR encephalitis Anti-GABAbR encephalitis Autoimmune encephalitis GABA receptors Systematic review

Mesh : Autoantibodies / immunology Autoantigens / immunology Autoimmune Diseases / immunology Encephalitis / immunology Humans Receptors, GABA-A / immunology Receptors, GABA-B / immunology Syndrome

来  源:   DOI:10.1016/j.jneuroim.2021.577804

Abstract:
The main objective of this article is to improve our understanding of the differences and similarities of these two anti-gamma-aminobutyric acid receptor encephalitis, anti-GABAaR and anti-GABAbR. The data were systematically collected and we found 26 studies: seven studies and 37 patients corresponded to anti-GABAaR encephalitis, and 21 manuscripts and 116 patients were diagnosed with anti-GABAbR encephalitis. Both anti-GABAR encephalitis were marked by prominent seizures. Anti-GABAaR patients were younger and showed multifocal encephalitis. On the other hand, anti-GABAbR patients were older and showed temporal limbic encephalitis. Tumor occurred in a fifth of anti-GABAaR encephalitis and in half of anti-GABAbR encephalitis. The main tumor associated with anti-GABAbR encephalitis is SCLC, whereas the most common tumor associated with anti-GABAaR encephalitis was thymoma. Our data confirms the differences in clinical features between both encephalitis.
摘要:
本文的主要目的是提高我们对这两种抗γ-氨基丁酸受体脑炎的异同的认识,抗GABAaR和抗GABAbR。系统收集了数据,我们发现了26项研究:7项研究和37例患者对应于抗GABAaR脑炎,21例手稿和116例患者被诊断患有抗GABAbR脑炎。两种抗GABAR脑炎均以明显的癫痫发作为特征。抗GABAaR患者年龄较小,表现为多灶性脑炎。另一方面,抗GABAbR患者年龄较大,并出现颞叶边缘叶脑炎.肿瘤发生在五分之一的抗GABAaR脑炎和一半的抗GABAbR脑炎中。与抗GABAbR脑炎相关的主要肿瘤是SCLC,而与抗GABAaR脑炎相关的最常见肿瘤是胸腺瘤。我们的数据证实了两种脑炎之间临床特征的差异。
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