Abstract：
OBJECTIVE: The objectives were to characterize clinico-pathologically a large series of peri-implant peripheral giant cell granuloma (PGCG), and investigate the role of foreign material as a possible etiological factor.
METHODS: The study was retrospective, conducted on peri-implant specimens submitted for histology between 2005 and 2021.
RESULTS: Three hundred and thirty-five peri-implant biopsies were retrieved, of which 52 (15.5%) were PGCG. The study population included 28 females and 24 males, age 35-92 years, mean 61. 51.2% reported bone involvement. The lesion involved the margins of the specimen in 65.3%, recurrence was reported in 46.1%. In 58.8% the implant was removed at the same time the specimen was submitted for histopathological analysis. Small foci of black granular foreign material were observed in 53.8% of cases of which 67.8% were birefringent under polarized light. The foreign material granules were not ingested inside multinucleated giant cells, but were scattered in the stromal compartment.
CONCLUSIONS: Peri-implant PGCG is locally aggressive, with frequent bone involvement and high recurrence rate, resulting in implant loss in the majority of cases. The high recurrence rate may be related to conservative or inadequate surgery. Foreign material although common does not seem to have a role in its development.
METHODS: The study was retrospective, conducted on peri-implant specimens submitted for histology between 2005 and 2021.
RESULTS: Three hundred and thirty-five peri-implant biopsies were retrieved, of which 52 (15.5%) were PGCG. The study population included 28 females and 24 males, age 35-92 years, mean 61. 51.2% reported bone involvement. The lesion involved the margins of the specimen in 65.3%, recurrence was reported in 46.1%. In 58.8% the implant was removed at the same time the specimen was submitted for histopathological analysis. Small foci of black granular foreign material were observed in 53.8% of cases of which 67.8% were birefringent under polarized light. The foreign material granules were not ingested inside multinucleated giant cells, but were scattered in the stromal compartment.
CONCLUSIONS: Peri-implant PGCG is locally aggressive, with frequent bone involvement and high recurrence rate, resulting in implant loss in the majority of cases. The high recurrence rate may be related to conservative or inadequate surgery. Foreign material although common does not seem to have a role in its development.
摘要：
目的：目的是描述一系列植入物周围周围巨细胞肉芽肿（PGCG）的临床病理学特征，并研究异物作为可能的病因的作用。
方法：本研究为回顾性研究，在2005年至2021年之间提交组织学的种植体周围标本上进行。
结果：检索到三百三十五个种植体周围活检，其中52（15.5%）为PGCG。研究人群包括28名女性和24名男性，年龄35-92岁,mean61.51.2%报告骨受累。病变累及标本边缘占65.3%，报告有46.1%的患者复发.在58.8％的情况下，在将标本提交组织病理学分析的同时，移除了植入物。在53.8％的病例中观察到黑色颗粒状异物的小病灶，其中67.8％在偏振光下双折射。异物颗粒没有被摄入多核巨细胞内部，但散落在基质隔间里.
结论：周围植入PGCG具有局部侵袭性，骨受累频繁，复发率高，在大多数情况下导致植入物丢失。高复发率可能与保守或不充分的手术有关。外国材料虽然常见，但似乎在其发展中没有作用。
方法：本研究为回顾性研究，在2005年至2021年之间提交组织学的种植体周围标本上进行。
结果：检索到三百三十五个种植体周围活检，其中52（15.5%）为PGCG。研究人群包括28名女性和24名男性，年龄35-92岁,mean61.51.2%报告骨受累。病变累及标本边缘占65.3%，报告有46.1%的患者复发.在58.8％的情况下，在将标本提交组织病理学分析的同时，移除了植入物。在53.8％的病例中观察到黑色颗粒状异物的小病灶，其中67.8％在偏振光下双折射。异物颗粒没有被摄入多核巨细胞内部，但散落在基质隔间里.
结论：周围植入PGCG具有局部侵袭性，骨受累频繁，复发率高，在大多数情况下导致植入物丢失。高复发率可能与保守或不充分的手术有关。外国材料虽然常见，但似乎在其发展中没有作用。
