Abstract：
Bipolar disorder shares symptoms and pathological pathways with other neurodegenerative diseases, including frontotemporal dementia (FTD). Since TAR DNA-binding protein 43 (TDP-43) is a neuropathological marker of frontotemporal dementia and it is involved in synaptic transmission, we explored the role of TDP-43 as a molecular feature of bipolar disorder (BD). Homogenates were acquired from frozen hippocampus of postmortem brains of bipolar disorder subjects. TDP-43 levels were quantified using an ELISA-sandwich method and compared between the postmortem brains of bipolar disorder subjects and age-matched control group. We found higher levels of TDP-43 protein in the hippocampus of BD (n = 15) subjects, when compared to controls (n = 15). We did not find associations of TDP-43 with age at death, postmortem interval, or age of disease onset. Our results suggest that protein TDP-43 may be potentially implicated in behavioral abnormalities seen in BD. Further investigation is needed to validate these findings and to examine the role of this protein during the disease course and mood states.
摘要：
双相情感障碍与其他神经退行性疾病有共同的症状和病理途径，包括额颞叶痴呆（FTD）。由于TARDNA结合蛋白43（TDP-43）是额颞叶痴呆的神经病理学标志物，它参与突触传递，我们探讨了TDP-43作为双相情感障碍(BD)分子特征的作用.匀浆是从双相情感障碍受试者死后大脑的冷冻海马中获得的。使用ELISA夹心法定量TDP-43水平，并在双相情感障碍受试者和年龄匹配的对照组的死后大脑之间进行比较。我们发现BD（n=15）受试者海马中TDP-43蛋白水平较高，与对照组相比（n=15）。我们没有发现TDP-43与死亡年龄有关，死后间隔,或发病年龄。我们的结果表明，蛋白质TDP-43可能与BD中的行为异常有关。需要进一步的研究来验证这些发现，并检查这种蛋白质在疾病过程和情绪状态中的作用。
