Immunopathology of RSV: An Updated Review.

RSV 的免疫病理学 ： 最新综述。

• 影响指数: 5.818
• 发表时间: 12 2021 10
• 来源期刊: Viruses
• DOI: 10.3390/v13122478
• PMID: 34960746
• 文章类型: Journal Article
• 中科院分区: Q2
• 方向: 医学
• 作者列表: Bergeron HC,Tripp RA

关键词: RSV; host–pathogen interaction; immunity; immunopathology; respiratory syncytial virus

Mesh: Adaptive Immunity; Animals; Disease Models, Animal; Humans; Immunity, Innate; Interferons / immunology metabolism; Respiratory Syncytial Virus Infections / epidemiology immunology prevention & control virology; Respiratory Syncytial Virus Vaccines / immunology; Respiratory Syncytial Virus, Human / immunology physiology

Abstract

RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding of virus-host interactions and immunity contribute to the lack of biological countermeasures. This review updates the current understanding of RSV immunity and immunopathology with a focus on interferon responses, animal modeling, and correlates of protection.

摘要

RSV是婴儿和老年人呼吸道疾病的主要原因。RSV的治疗干预措施有限，没有FDA批准的疫苗。我们对病毒与宿主相互作用和免疫力的理解存在差距，导致缺乏生物学对策。这篇综述更新了当前对RSV免疫和免疫病理学的理解，重点是干扰素反应。动物建模,与保护有关。