Abstract：
Storage in aqueous solution or ultraviolet (UV) irradiation can retain or regain the hydrophilicity of titanium implant surface. In this study, 3 types of commercial titanium implants were used: ZBL (ZDI Bone Level), CEL (C-tech Esthetic Line), and modSLA (Straumann SLActive). ZBL and CEL implants were treated with UV irradiation for 4 hours. Surface characterization of the 4 groups (ZBL, ZBL-UV, CEL-UV, and modSLA) was evaluated by scanning electron microscopy and contact angle measurements. The in vivo bone response was evaluated by removal torque (RTQ) tests and histomorphometric analysis at 3, 6, and 12 weeks postimplantation. A total of 144 implants and 36 rabbits were used for experiments according to a previously established randomization sequence. The ZBL-UV, CEL-UV, and modSLA groups were hydrophilic, and nanostructures were observed on the modSLA implant surface. ModSLA achieved better RTQ value than ZBL at 12 weeks (P < .05). For histomorphometric analysis, ZBL-UV and CEL-UV implants showed higher bone area values in the cancellous bone zone at 6 weeks than did modSLA and ZBL implants (P < .05). In the cortical bone zone, all groups showed comparable bone-to-implant contact at all healing time points (P > .05). Both storage in saline and UV irradiation could retain or provoke hydrophilic surfaces and improve osseointegration. Compared with storage in saline, UV irradiation displayed slight advantages in promoting new bone formation in cancellous bone zone at an early stage.
摘要：
在水溶液或紫外线（UV）照射中储存可以保留或恢复钛植入物表面的亲水性。在这项研究中,使用了3种类型的商业钛植入物：ZBL（ZDI骨水平），CEL（C-tech美感线），和modSLA(StraumannSLActive)。用UV照射处理ZBL和CEL植入物4小时。4基团的表面表征(ZBL，ZBL-UV,CEL-UV,和modSLA）通过扫描电子显微镜和接触角测量进行评估。在植入后3、6和12周时，通过去除扭矩（RTQ）测试和组织形态分析评估体内骨反应。根据先前建立的随机化顺序,总共144个植入物和36只兔子用于实验。ZBL-UV,CEL-UV,和modSLA组是亲水的，在modSLA植入物表面观察到纳米结构。ModSLA在12周时的RTQ值优于ZBL（P<0.05）。对于组织形态分析，ZBL-UV和CEL-UV植入物在6周时在松质骨区显示出比modSLA和ZBL植入物更高的骨面积值(P<.05)。在皮质骨区，在所有愈合时间点,所有组的骨-种植体接触均具有可比性(P>.05).在盐水中储存和紫外线照射都可以保留或激发亲水表面并改善骨整合。与在盐水中储存相比，紫外线照射在早期促进松质骨区新骨形成方面显示出轻微的优势。
