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Abstract：
Background: Excess selenium has been related with adverse lipid levels in previous epidemiological studies. Meanwhile, a functional variant in SEPP1 (encodes selenoprotein P), namely rs7579, has been suggested to modulate lipid metabolism. However, the interactions between selenium status and rs7579 polymorphism on lipid changes remain unclear. Objective: To examine whether the associations between plasma selenium and 3-year lipid changes is modified by rs7579 polymorphism. Methods: A prospective cohort study was conducted among 1,621 individuals to examine the associations between baseline plasma selenium and 3-year lipid changes, as well as the interactions between plasma selenium and rs7579 polymorphism on lipid changes. Results: The median (interquartile range) concentration of plasma selenium was 91.68 (81.55-104.92) μg/L. Higher plasma selenium was associated with adverse 3-year lipid changes. Comparing the highest to the lowest quartiles of plasma selenium concentrations, 3-year lipid changes were elevated by 8.25% (95% CI: 1.54-14.96%) for triglycerides (P = 0.016), 5.88% (3.13-8.63%) for total cholesterol (P < 0.001), 7.37% (3.07-11.67%) for low-density lipoprotein cholesterol (P = 0.0008), 6.44% (2.66-10.21%) for non-high-density lipoprotein cholesterol (P = 0.0009), 4.99% (0.62-9.36%) for total cholesterol/high-density lipoprotein cholesterol ratio (P = 0.025), and 7.00% (1.55-12.46%) for low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (P = 0.012). In analyses stratified by rs7579 genotypes, positive associations between plasma selenium concentrations and 3-year changes in triglycerides, TC, LDL-C, non-HDL-C, TC/HDL-C ratio, and LDL-C/HDL-C ratio were observed among CC genotype carriers, but negative associations between plasma selenium and TC/HDL-C ratio, and LDL-C/HDL-C ratio were observed among TT genotype carriers. Conclusions: Our findings suggested that plasma selenium was associated with 3-year lipid changes differentially by rs7579 genotypes, and higher plasma selenium was associated with adverse lipid changes among rs7579 CC genotype carriers, but not among T allele carriers.
摘要：
背景：在先前的流行病学研究中，过量的硒与不良的脂质水平有关。同时,SEPP1中的功能变体（编码硒蛋白P），即rs7579，已被建议调节脂质代谢。然而,硒状态和rs7579多态性对血脂变化的相互作用尚不清楚。目的：研究rs7579多态性是否改变了血浆硒与3年血脂变化之间的关系。方法：在1,621名个体中进行了一项前瞻性队列研究，以检查基线血浆硒与3年血脂变化之间的关联。以及血浆硒和rs7579多态性对血脂变化的相互作用。结果：血浆硒的中位数（四分位数范围）浓度为91.68（81.55-104.92）μg/L。较高的血浆硒与不良的3年血脂变化有关。比较血浆硒浓度的最高和最低四分位数，甘油三酯的3年血脂变化升高8.25%（95%CI：1.54-14.96%）（P=0.016），总胆固醇为5.88%(3.13-8.63%)(P<0.001),低密度脂蛋白胆固醇为7.37%(3.07-11.67%)(P=0.0008),非高密度脂蛋白胆固醇为6.44％（2.66-10.21％）（P=0.0009），总胆固醇/高密度脂蛋白胆固醇比值4.99%(0.62-9.36%)(P=0.025),低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值为7.00%(1.55-12.46%)(P=0.012)。在按rs7579基因型分层的分析中，血浆硒浓度与甘油三酯3年变化之间的正相关，TC,LDL-C,非HDL-C,TC/HDL-C比值,在CC基因型携带者中观察到LDL-C/HDL-C比率，但血浆硒与TC/HDL-C比值呈负相关，在TT基因型携带者中观察到LDL-C/HDL-C比率。结论：我们的发现表明，血浆硒与rs7579基因型的3年血脂变化有关，较高的血浆硒与rs7579CC基因型携带者的血脂不良变化有关，但不是在T等位基因携带者中。
