Abstract：
BACKGROUND: To identify the capsule enlargement index after femtosecond laser-assisted anterior capsulorhexis in 2-6-year-old children who underwent congenital cataract surgery.
METHODS: In this prospective case series study, femtosecond laser-assisted anterior capsulorhexis was performed in patients with congenital cataract, aged 2-6 years. The actual achieved capsulorhexis diameters were measured with Digimizer version 4.2.6. Correlation coefficient (r) and multiple linear regression analysis were used to evaluate the variables that could potentially influence anterior capsulorhexis enlargement index (E).
RESULTS: This prospective study enrolled 28 eyes of 22 patients with congenital cataract. The mean age of the patients at surgery was 4.67 years ±1.54 (standard deviation [SD]). \"E\" of the 28 cases was 1.211 ± 0.039 (SD). Correlation analysis showed that \"E\" correlated significantly with the anterior chamber depth (ACD) (r = - 0.469, p = 0.021) and axial length (AL) (r = 0.452, p = 0.027). The following formula was developed by using multivariable linear regression analysis: Predicted E = 1.177-0.052 × ACD + 0.009 × AL, R2 = 0.346 (F = 4.396, p = 0.046).
CONCLUSIONS: The anterior capsulorhexis enlargement index and its calculation formula could help to set up an accurate programmed capsulorhexis diameter for femtosecond laser-assisted congenital cataract surgery in children aged 2-6 years. Thus, an appropriate actual capsulorhexis diameter could be achieved.
METHODS: In this prospective case series study, femtosecond laser-assisted anterior capsulorhexis was performed in patients with congenital cataract, aged 2-6 years. The actual achieved capsulorhexis diameters were measured with Digimizer version 4.2.6. Correlation coefficient (r) and multiple linear regression analysis were used to evaluate the variables that could potentially influence anterior capsulorhexis enlargement index (E).
RESULTS: This prospective study enrolled 28 eyes of 22 patients with congenital cataract. The mean age of the patients at surgery was 4.67 years ±1.54 (standard deviation [SD]). \"E\" of the 28 cases was 1.211 ± 0.039 (SD). Correlation analysis showed that \"E\" correlated significantly with the anterior chamber depth (ACD) (r = - 0.469, p = 0.021) and axial length (AL) (r = 0.452, p = 0.027). The following formula was developed by using multivariable linear regression analysis: Predicted E = 1.177-0.052 × ACD + 0.009 × AL, R2 = 0.346 (F = 4.396, p = 0.046).
CONCLUSIONS: The anterior capsulorhexis enlargement index and its calculation formula could help to set up an accurate programmed capsulorhexis diameter for femtosecond laser-assisted congenital cataract surgery in children aged 2-6 years. Thus, an appropriate actual capsulorhexis diameter could be achieved.
摘要：
背景：为了确定接受先天性白内障手术的2-6岁儿童在飞秒激光辅助前囊撕除后的囊扩大指数。
方法：在本前瞻性病例系列研究中，对先天性白内障患者进行了飞秒激光辅助的前囊撕除，2-6岁。使用Digimizer版本4.2.6测量实际实现的撕囊直径。使用相关系数（r）和多元线性回归分析来评估可能影响前撕囊扩大指数（E）的变量。
结果：这项前瞻性研究纳入了22例先天性白内障患者的28只眼。手术患者的平均年龄为4.67岁±1.54（标准差[SD]）。28例中，“E”为1.211±0.039（SD）。相关分析表明，“E”与前房深度（ACD）（r=-0.469，p=0.021）和轴向长度（AL）（r=0.452，p=0.027）显着相关。通过多元线性回归分析得出以下公式:预测E=1.177-0.052×ACD+0.009×AL,R2=0.346(F=4.396,p=0.046)。
结论：前撕囊扩大指数及其计算公式有助于为2-6岁儿童飞秒激光辅助先天性白内障手术建立准确的程序撕囊直径。因此，可以实现适当的实际撕囊直径。
方法：在本前瞻性病例系列研究中，对先天性白内障患者进行了飞秒激光辅助的前囊撕除，2-6岁。使用Digimizer版本4.2.6测量实际实现的撕囊直径。使用相关系数（r）和多元线性回归分析来评估可能影响前撕囊扩大指数（E）的变量。
结果：这项前瞻性研究纳入了22例先天性白内障患者的28只眼。手术患者的平均年龄为4.67岁±1.54（标准差[SD]）。28例中，“E”为1.211±0.039（SD）。相关分析表明，“E”与前房深度（ACD）（r=-0.469，p=0.021）和轴向长度（AL）（r=0.452，p=0.027）显着相关。通过多元线性回归分析得出以下公式:预测E=1.177-0.052×ACD+0.009×AL,R2=0.346(F=4.396,p=0.046)。
结论：前撕囊扩大指数及其计算公式有助于为2-6岁儿童飞秒激光辅助先天性白内障手术建立准确的程序撕囊直径。因此，可以实现适当的实际撕囊直径。
