METHODS: Scoping review methodology was utilized to identify studies, extract data, and collate and summarize results.
RESULTS: In literature published from January 2010 through to August 2021, only one human study and three pre-clinical studies met inclusion criteria.
CONCLUSIONS: Existing evidence supports that physical activity is associated with decreased treatment-related toxicities such as CRF. However, further investigation is warranted. The dearth of clinical studies illustrates the need for more research to address this question, to guide patients and their providers in the application of appropriate physical activity interventions in those patients undergoing ICI.
方法:使用范围审查方法来确定研究,提取数据,并整理和总结结果。
结果:在2010年1月至2021年8月发表的文献中,只有一项人体研究和三项临床前研究符合纳入标准。
结论:现有证据支持体力活动与降低治疗相关毒性如CRF相关。然而,需要进一步调查。缺乏临床研究说明需要更多的研究来解决这个问题,指导患者及其提供者在接受ICI的患者中应用适当的身体活动干预措施。