Abstract：
BACKGROUND: Cancer therapies are associated with multiple adverse effects, including (but not limited to) cancer-related fatigue (CRF). Fatigue is one of the most common side effects of immune checkpoint inhibitors (ICIs), occurring in up to 25% of patients. Physical activity has been shown to help reduce CRF through modulating the immune system, and may synergistically aid in the anti-tumor effects of ICIs. This review describes the nature and scope of evidence for the effects associated with concurrent physical activity while undergoing ICI therapy.
METHODS: Scoping review methodology was utilized to identify studies, extract data, and collate and summarize results.
RESULTS: In literature published from January 2010 through to August 2021, only one human study and three pre-clinical studies met inclusion criteria.
CONCLUSIONS: Existing evidence supports that physical activity is associated with decreased treatment-related toxicities such as CRF. However, further investigation is warranted. The dearth of clinical studies illustrates the need for more research to address this question, to guide patients and their providers in the application of appropriate physical activity interventions in those patients undergoing ICI.
METHODS: Scoping review methodology was utilized to identify studies, extract data, and collate and summarize results.
RESULTS: In literature published from January 2010 through to August 2021, only one human study and three pre-clinical studies met inclusion criteria.
CONCLUSIONS: Existing evidence supports that physical activity is associated with decreased treatment-related toxicities such as CRF. However, further investigation is warranted. The dearth of clinical studies illustrates the need for more research to address this question, to guide patients and their providers in the application of appropriate physical activity interventions in those patients undergoing ICI.
摘要：
背景：癌症治疗与多种不良反应相关，包括（但不限于）癌症相关性疲劳（CRF）。疲劳是免疫检查点抑制剂（ICIs）最常见的副作用之一。发生在高达25％的患者。身体活动已被证明可以通过调节免疫系统来帮助减少CRF，并且可以协同地帮助ICIs的抗肿瘤作用。这篇综述描述了在进行ICI治疗时与并发体力活动相关的影响的证据的性质和范围。
方法：使用范围审查方法来确定研究，提取数据，并整理和总结结果。
结果：在2010年1月至2021年8月发表的文献中，只有一项人体研究和三项临床前研究符合纳入标准。
结论：现有证据支持体力活动与降低治疗相关毒性如CRF相关。然而,需要进一步调查。缺乏临床研究说明需要更多的研究来解决这个问题，指导患者及其提供者在接受ICI的患者中应用适当的身体活动干预措施。
方法：使用范围审查方法来确定研究，提取数据，并整理和总结结果。
结果：在2010年1月至2021年8月发表的文献中，只有一项人体研究和三项临床前研究符合纳入标准。
结论：现有证据支持体力活动与降低治疗相关毒性如CRF相关。然而,需要进一步调查。缺乏临床研究说明需要更多的研究来解决这个问题，指导患者及其提供者在接受ICI的患者中应用适当的身体活动干预措施。
