Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy.

• 发表时间: Oct 2021
• 来源期刊: Phys Imaging Radiat Oncol
• DOI: 10.1016/j.phro.2021.11.005
• PMID: 34917780
• 文章类型: Journal Article
• 作者列表: Hofmaier J,Walter F,Hadi I,Rottler M,von Bestenbostel R,Dedes G,Parodi K,Niyazi M,Belka C,Kamp F,Hofmaier J,Walter F,Hadi I,Rottler M,von Bestenbostel R,Dedes G,Parodi K,Niyazi M,Belka C,Kamp F

关键词: Inter-observer variability; Proton therapy; Range uncertainty; Sensitivity analysis; Setup uncertainty; Inter-observer variability; Proton therapy; Range uncertainty; Sensitivity analysis; Setup uncertainty

Abstract

Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range uncertainty in a variance-based sensitivity analysis (SA). For ten patients with skull base meningioma, the mean calculation time to perform the SA including 1.6 × 104 dose recalculations was 59 min. For two patients in this dataset, IOV had a relevant impact on the estimated CTV D95% uncertainty.