PDF(Pubmed)
Abstract：
Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity in patients with cystic fibrosis (CF). Prevalence of CFRD increases with age and is greater with severe mutations. Other risk factors associated with CFRD are female sex, pancreatic insufficiency, liver disease, need for gastrostomy tube feedings, history of bronchopulmonary aspergillosis, and poor pulmonary function. CFRD is related to worse clinical outcomes and increased mortality. Early diagnosis and treatment have been shown to improve clinical outcomes. Screening for CFRD is recommended with an annual oral glucose tolerance test (OGTT) starting at age 10 years. Diagnosis of CFRD is made by standard American Diabetes Association (ADA) criteria during baseline health. CFRD can also be diagnosed in individuals with CF during acute illness, while on enteral feeds, and after transplant. In this review we will discuss the epidemiology of CFRD and provide an overview of the advantages and pitfalls of current screening and diagnostic tests for CFRD.
摘要：
囊性纤维化相关糖尿病（CFRD）是囊性纤维化（CF）患者中最常见的合并症。CFRD的患病率随着年龄的增长而增加，并且随着严重突变而增加。与CFRD相关的其他危险因素是女性，胰腺功能不全,肝病,需要胃造瘘管喂养，支气管肺曲霉病病史，肺功能差.CFRD与较差的临床结果和增加的死亡率有关。早期诊断和治疗已被证明可以改善临床结果。建议从10岁开始进行年度口服葡萄糖耐量试验（OGTT），以筛查CFRD。CFRD的诊断是在基线健康期间通过标准的美国糖尿病协会(ADA)标准进行的。CFRD也可以在急性疾病期间诊断为CF患者，在肠内喂养时，移植后。在这篇综述中，我们将讨论CFRD的流行病学，并概述当前CFRD筛查和诊断测试的优点和缺陷。
