Abstract：
For many years, coagulase-negative staphylococci (CoNS) have been considered non-pathogenic bacteria. However, recently, CoNS are becoming more common bacteriological factors isolated from cases of chronic rhinosinusitis in humans. Moreover, most of them represent the multidrug-resistant or/and methicillin-resistant profile, which significantly increases the therapeutic difficulties. The aim of the study was to characterize profile of resistant coagulase-negative staphylococci isolated from cases of chronic rhinosinusitis in patients treated in a Medical Center in Warsaw in 2015-2016. The study material was derived from patients with diagnosed chronic rhinosinusitis treated at the MML Medical Center in Warsaw. The material was obtained intraoperatively from maxillary, frontal, and ethmoid sinuses. In total, 1,044 strains were isolated from the studied material. Coagulase-negative staphylococci were predominant, with the largest share of Staphylococcus epidermidis. Isolated CoNS were mainly resistant to macrolide, lincosamide, and tetracycline. Among the S. epidermidis strains, we also showed 35.6% of MDR and 34.7% of methicillin-resistant strains. The same values for other non-epidermidis species were 31.5% and 18.5%, respectively and the percentage of strains with MAR >0.2 was greater in S. epidermidis (32.6%) than S. non-epidermidis (23.9%). Although the percentage of strains resistant to tigecycline, glycopeptides, rifampicin and oxazolidinones was very small (2.3%, 1.9%, 1.4% and 0.7% respectively), single strains were reported in both groups. The study has shown a high proportion of MDR and methicillin-resistant CoNS strains, which indicates a large share of drug-resistant microorganisms in the process of persistence of chronic rhinosinusitis; therefore, isolation of this group of microorganisms from clinical cases using aseptic techniques should not be neglected.
摘要：
多年来,凝固酶阴性葡萄球菌(CoNS)被认为是非致病菌.然而,最近,CoNS正在成为从人类慢性鼻-鼻窦炎病例中分离出的更常见的细菌学因素。此外，其中大多数代表耐多药或/和耐甲氧西林的概况，这大大增加了治疗困难。该研究的目的是描述2015-2016年在华沙医疗中心接受治疗的患者从慢性鼻-鼻窦炎病例中分离出的耐药凝固酶阴性葡萄球菌的特征。研究材料来自华沙MML医学中心治疗的诊断为慢性鼻-鼻窦炎的患者。该材料在术中从上颌骨获得，额叶,和筛窦。总的来说,从所研究的材料中分离出1,044个菌株。凝固酶阴性葡萄球菌占优势，表皮葡萄球菌的份额最大。分离的CoNS主要对大环内酯耐药，lincosamide,还有四环素.在表皮葡萄球菌菌株中，我们还显示了35.6％的MDR和34.7％的耐甲氧西林菌株。其他非表皮物种的相同值分别为31.5％和18.5％，MAR>0.2的菌株在表皮葡萄球菌中的百分比(32.6%)高于非表皮葡萄球菌(23.9%)。尽管对替加环素耐药的菌株百分比，糖肽，利福平和恶唑烷酮类很小(2.3%，1.9%，分别为1.4%和0.7%），两组均报告了单一菌株。该研究表明，耐多药和耐甲氧西林CoNS菌株的比例很高，这表明在慢性鼻窦炎持续存在的过程中，耐药微生物占很大比例;因此，不应忽略使用无菌技术从临床病例中分离这组微生物。
