Abstract：
Recent evidence links trimethylamine oxide (TMAO) to endothelial dysfunction, an early indicator of cardiovascular disease. We aimed to determine whether short-term consumption of a diet patterned after the 2010 Dietary Guidelines for Americans (DGA) would affect endothelial function, plasma TMAO concentrations, and cardiovascular disease risk, differently than a typical American Diet (TAD).
An 8-wk controlled feeding trial was conducted in overweight/obese women pre-screened for insulin resistance and/or dyslipidemia. Women were randomized to a DGA or TAD group (n = 22/group). At wk0 (pre-intervention) and wk8 (post-intervention) vascular age was calculated; endothelial function (reactive hyperemia index (RHI)) and augmentation index (AI@75) were measured using EndoPAT, and plasma TMAO was measured by LC-MS/MS. Vascular age was reduced in DGA at wk8 compared to wk0 but TAD wk8 was not different from wk0 (DGA wk0: 54.2 ± 4.0 vs. wk8: 50.5 ± 3.1 (p = 0.05), vs. TAD wk8: 47.7 ± 2.3). Plasma TMAO concentrations, RHI, and AI@75 were not different between groups or weeks.
Consumption of a diet based on the 2010 Dietary Guidelines for Americans for 8 weeks did not improve endothelial function or reduce plasma TMAO. CLINICALTRIALS.GOV: NCT02298725.
An 8-wk controlled feeding trial was conducted in overweight/obese women pre-screened for insulin resistance and/or dyslipidemia. Women were randomized to a DGA or TAD group (n = 22/group). At wk0 (pre-intervention) and wk8 (post-intervention) vascular age was calculated; endothelial function (reactive hyperemia index (RHI)) and augmentation index (AI@75) were measured using EndoPAT, and plasma TMAO was measured by LC-MS/MS. Vascular age was reduced in DGA at wk8 compared to wk0 but TAD wk8 was not different from wk0 (DGA wk0: 54.2 ± 4.0 vs. wk8: 50.5 ± 3.1 (p = 0.05), vs. TAD wk8: 47.7 ± 2.3). Plasma TMAO concentrations, RHI, and AI@75 were not different between groups or weeks.
Consumption of a diet based on the 2010 Dietary Guidelines for Americans for 8 weeks did not improve endothelial function or reduce plasma TMAO. CLINICALTRIALS.GOV: NCT02298725.
摘要：
最近的证据表明三甲胺氧化物（TMAO）与内皮功能障碍，心血管疾病的早期指标。我们的目的是确定短期食用以2010年美国人饮食指南（DGA）为模式的饮食是否会影响内皮功能，血浆TMAO浓度，和心血管疾病的风险，与典型的美国饮食（TAD）不同。
一项为期8周的控制喂养试验是在超重/肥胖妇女中进行的，这些妇女预先筛查了胰岛素抵抗和/或血脂异常。妇女被随机分为DGA或TAD组（n=22/组）。在wk0（干预前）和wk8（干预后）计算血管年龄；使用EndoPAT测量内皮功能（反应性充血指数（RHI））和增强指数（AI@75），通过LC-MS/MS测量血浆TMAO。与wk0相比，wk8时DGA的血管年龄降低，但TADwk8与wk0没有差异（DGAwk0：54.2±4.0vs.wk8：50.5±3.1（p=0.05），vs.TADwk8:47.7±2.3)。血浆TMAO浓度，RHI,和AI@75在组间或周之间没有差异。
消费基于2010年美国人饮食指南的饮食8周没有改善内皮功能或降低血浆TMAO。临床医师。GOV：NCT02298725。
一项为期8周的控制喂养试验是在超重/肥胖妇女中进行的，这些妇女预先筛查了胰岛素抵抗和/或血脂异常。妇女被随机分为DGA或TAD组（n=22/组）。在wk0（干预前）和wk8（干预后）计算血管年龄；使用EndoPAT测量内皮功能（反应性充血指数（RHI））和增强指数（AI@75），通过LC-MS/MS测量血浆TMAO。与wk0相比，wk8时DGA的血管年龄降低，但TADwk8与wk0没有差异（DGAwk0：54.2±4.0vs.wk8：50.5±3.1（p=0.05），vs.TADwk8:47.7±2.3)。血浆TMAO浓度，RHI,和AI@75在组间或周之间没有差异。
消费基于2010年美国人饮食指南的饮食8周没有改善内皮功能或降低血浆TMAO。临床医师。GOV：NCT02298725。
