Abstract：
In recent years, several case-control studies have explored the association between the rs7763881 locus polymorphism of the HULC gene and cancer risk, however, the findings have been inconsistent. Therefore, a meta-analysis was conducted to clarify the association. Relevant case-control studies were obtained from CNKI, Embase, Web of Science and PubMed databases. RevMan software was used to perform data analysis. A total of 8 case-control studies containing 4036 cases and 5286 controls were included in the current meta-analysis. The overall analysis results showed no significant association between the rs7763881 locus polymorphism and cancer risk. However, stratified analysis based on cancer type showed that the rs7763881 locus polymorphism was associated with the decreased risk of hepatocellular cancer, colorectal cancer and esophageal cancer. In conclusion, the current findings suggest that the rs7763881 polymorphic loci located on the HULC gene may serve as a biomarker for determining an individual\'s risk of hepatocellular cancer, colorectal cancer and esophageal cancer.
摘要：
近年来,一些病例对照研究探索了HULC基因rs7763881位点多态性与癌症风险之间的关联，然而,调查结果不一致。因此,本研究进行了荟萃分析以阐明其相关性.相关病例对照研究来自CNKI，Embase,WebofScience和PubMed数据库。采用RevMan软件进行数据分析。共有8项病例对照研究，包括4036例病例和5286例对照纳入当前的荟萃分析。总体分析结果显示rs7763881基因座多态性与癌症风险之间没有显着关联。然而,基于癌症类型的分层分析显示，rs7763881位点多态性与肝细胞癌风险降低相关，结直肠癌和食道癌。总之,目前的研究结果表明，位于HULC基因上的rs7763881多态位点可以作为确定个体肝细胞癌风险的生物标志物，结直肠癌和食道癌。
