Abstract：
BACKGROUND: A large discrepancy between physician-diagnosed and self-reported HS exists. Knowledge regarding incidence and remission rates of self-reported HS is missing, but may help bridge the gap in understanding between these two phenotypes.
OBJECTIVE: To determine the incidence and remission rates of self-reported HS, and to what degree these are affected by sex, smoking and BMI.
METHODS: A prospective cohort of 23,930 Danish blood donors. Information on self-reported HS, symptom-localization, sex, age, BMI and smoking status was collected at baseline and study termination. Self-reported HS fulfilled clinical obligatory diagnostic criteria. Cox proportional hazards regression analyses were conducted for both incidence and remission rates providing a hazard ratio (HR) of risk for each variable in the regression.
RESULTS: incidence rate of self-reported HS was 10.8/1,000 person-years (95% CI: 9.9-11.7), decreasing as a function of numbers of areas affected. Female BMI points above 25 (HR=1.11, 95% CI: 1.09-1.13), male BMI points above 25 (HR=1.07, 95% CI: 1.04-1.11) , active smoking (HR=1.72, 95% CI: 1.15-2.57), male sex (HR=0.55, 95% CI: 0.45-0.67) and years of age above 25 (HR=0.97, 95% CI: 0.96-0.97) were all statistically associated with the development of self-reported HS. Remission rate of self-reported HS was 256.7/1,000 person-years (95% CI: 223.9-292.6), decreasing as a function of numbers of affected areas. Symptoms in ≥3 areas (HR=0.54, 95% CI: 0.34-0.85), active smoking (HR=0.49, 95% CI: 0.32-0.76) and female weight loss (every percentage drop in BMI: HR=1.07, 95%CI: 1.05-1.11) all significantly affected the remission rate.
CONCLUSIONS: Both incidence and remission rates of self-reported HS are high, indicating that many with self-reported HS are unlikely to be diagnosed, as they to a higher degree experience mild transient HS symptoms.
OBJECTIVE: To determine the incidence and remission rates of self-reported HS, and to what degree these are affected by sex, smoking and BMI.
METHODS: A prospective cohort of 23,930 Danish blood donors. Information on self-reported HS, symptom-localization, sex, age, BMI and smoking status was collected at baseline and study termination. Self-reported HS fulfilled clinical obligatory diagnostic criteria. Cox proportional hazards regression analyses were conducted for both incidence and remission rates providing a hazard ratio (HR) of risk for each variable in the regression.
RESULTS: incidence rate of self-reported HS was 10.8/1,000 person-years (95% CI: 9.9-11.7), decreasing as a function of numbers of areas affected. Female BMI points above 25 (HR=1.11, 95% CI: 1.09-1.13), male BMI points above 25 (HR=1.07, 95% CI: 1.04-1.11) , active smoking (HR=1.72, 95% CI: 1.15-2.57), male sex (HR=0.55, 95% CI: 0.45-0.67) and years of age above 25 (HR=0.97, 95% CI: 0.96-0.97) were all statistically associated with the development of self-reported HS. Remission rate of self-reported HS was 256.7/1,000 person-years (95% CI: 223.9-292.6), decreasing as a function of numbers of affected areas. Symptoms in ≥3 areas (HR=0.54, 95% CI: 0.34-0.85), active smoking (HR=0.49, 95% CI: 0.32-0.76) and female weight loss (every percentage drop in BMI: HR=1.07, 95%CI: 1.05-1.11) all significantly affected the remission rate.
CONCLUSIONS: Both incidence and remission rates of self-reported HS are high, indicating that many with self-reported HS are unlikely to be diagnosed, as they to a higher degree experience mild transient HS symptoms.
摘要：
背景：医生诊断和自我报告的HS之间存在很大差异。关于自我报告HS的发生率和缓解率的知识缺失，但可能有助于弥合这两种表型之间的理解差距。
目的：为了确定自我报告的HS的发生率和缓解率，这些受性别影响的程度，吸烟和BMI
方法：由23,930名丹麦献血者组成的前瞻性队列。关于自我报告HS的信息，症状定位，性别,年龄,在基线和研究终止时收集BMI和吸烟状况。自我报告的HS符合临床强制性诊断标准。对发病率和缓解率进行Cox比例风险回归分析，为回归中的每个变量提供风险比（HR）。
结果：自我报告HS的发生率为10.8/1,000人年（95％CI：9.9-11.7），随着受影响地区数量的增加而减少。女性BMI高于25（HR=1.11，95%CI：1.09-1.13），男性BMI高于25（HR=1.07，95%CI：1.04-1.11），主动吸烟（HR=1.72，95%CI：1.15-2.57），男性(HR=0.55,95%CI:0.45-0.67)和25岁以上(HR=0.97,95%CI:0.96-0.97)均与自我报告HS的发展有统计学关联.自我报告HS的缓解率为256.7/1,000人年（95％CI：223.9-292.6），随着受影响地区数量的增加而减少。≥3个地区的症状（HR=0.54，95％CI：0.34-0.85），主动吸烟(HR=0.49,95%CI:0.32-0.76)和女性体重下降(BMI每下降一个百分比:HR=1.07,95CI:1.05-1.11)均显著影响缓解率.
结论：自我报告的HS的发生率和缓解率都很高，表明许多自我报告的HS不太可能被诊断出来，因为他们在更高的程度上经历轻度短暂的HS症状。
目的：为了确定自我报告的HS的发生率和缓解率，这些受性别影响的程度，吸烟和BMI
方法：由23,930名丹麦献血者组成的前瞻性队列。关于自我报告HS的信息，症状定位，性别,年龄,在基线和研究终止时收集BMI和吸烟状况。自我报告的HS符合临床强制性诊断标准。对发病率和缓解率进行Cox比例风险回归分析，为回归中的每个变量提供风险比（HR）。
结果：自我报告HS的发生率为10.8/1,000人年（95％CI：9.9-11.7），随着受影响地区数量的增加而减少。女性BMI高于25（HR=1.11，95%CI：1.09-1.13），男性BMI高于25（HR=1.07，95%CI：1.04-1.11），主动吸烟（HR=1.72，95%CI：1.15-2.57），男性(HR=0.55,95%CI:0.45-0.67)和25岁以上(HR=0.97,95%CI:0.96-0.97)均与自我报告HS的发展有统计学关联.自我报告HS的缓解率为256.7/1,000人年（95％CI：223.9-292.6），随着受影响地区数量的增加而减少。≥3个地区的症状（HR=0.54，95％CI：0.34-0.85），主动吸烟(HR=0.49,95%CI:0.32-0.76)和女性体重下降(BMI每下降一个百分比:HR=1.07,95CI:1.05-1.11)均显著影响缓解率.
结论：自我报告的HS的发生率和缓解率都很高，表明许多自我报告的HS不太可能被诊断出来，因为他们在更高的程度上经历轻度短暂的HS症状。
