Abstract：
We studied the possibility of using sodium deoxyribonucleate (Derinat) for improving the efficiency of co-transplantation of mesenchymal (MSC) and hematopoietic stem cells (HSC) to female F1(CBA×C57BL/6) mice with bone marrow aplasia caused by exposure to γ-radiation. It was found that immunomodulator Derinat enhanced the effect of co-transplantation, in particular, triple post-irradiation administration of Derinat accelerated hematopoiesis recovery judging from the parameters of peripheral blood, total cellularity of the bone marrow and spleen, and animal survival. Single or double administration of Derinat prior to irradiation was ineffective. The optimal result was obtained when the following scheme was applied: MSC→HSC with an interval of 48 h starting during the first hours after irradiation and triple administration of Derinat (in 10-15 min, 3 and 7 days after irradiation) in a dose of 3 mg/mouse.
摘要：
我们研究了使用脱氧核糖核酸钠（Derinat）提高间充质（MSC）和造血干细胞（HSC）共移植到雌性F1（CBA×C57BL/6）小鼠骨髓增生的效率的可能性暴露于γ辐射。发现免疫调节剂Derinat增强了共移植的效果，特别是,从外周血参数判断Derinat的三重照射后加速造血恢复，骨髓和脾脏的细胞总数，动物的生存在照射前单次或两次施用Derinat无效。当应用以下方案时，获得最佳结果：MSC→HSC，在辐射和Derinat的三重给药后的第一个小时内开始，间隔为48小时（在10-15分钟内，照射后3和7天），剂量为3mg/小鼠。
