PDF(Pubmed)
Abstract：
Mucormycosis represents several unusual opportunistic infection caused by saprophytic aseptate fungi. There is a recent rise in cases of mucormycosis due to an increase in diabetic and immunodeficient patients like patients on long-term steroids, immunomodulators due to organ transplantation, malignancies, mainly haematological malignancies, and autoimmunity. Anatomically, mucormycosis can be localised most commonly as rhino-orbito-cerebral followed by pulmonary, disseminated, cutaneous and gastrointestinal, rarest being small intestinal. Patients with Down syndrome are immunodeficient due to their impaired immune response. Disseminated tuberculosis is also common in immunodeficient patients. We report a rare case of small intestinal mucormycosis in a patient with Down syndrome with coexisting intestinal tuberculosis. Due to the invasiveness of mucormycosis, the patient succumbed to death despite providing aggressive surgical debridement and medical management.
摘要：
毛霉菌病代表了由腐生无菌体真菌引起的几种不寻常的机会性感染。由于糖尿病和免疫缺陷患者的增加，如长期使用类固醇的患者，最近毛霉菌病的病例有所增加，器官移植引起的免疫调节剂,恶性肿瘤,主要是血液恶性肿瘤，和自身免疫。解剖学上,毛霉菌病最常见的是犀牛或大脑，其次是肺部，传播,皮肤和胃肠，最罕见的是小肠。患有唐氏综合征的患者由于其受损的免疫应答而具有免疫缺陷。播散性结核病在免疫缺陷患者中也很常见。我们报告了一例罕见的唐氏综合征合并肠结核的小肠毛霉菌病。由于毛霉菌病的侵袭性,尽管提供了积极的手术清创和医疗管理，但患者仍死于死亡。
