PDF(Pubmed)
Abstract：
Although gastroschisis is often diagnosed by prenatal ultrasound, there is still a gap in the literature about which prenatal ultrasound markers can predict complex gastroschisis. This systematic review and meta-analysis aimed to investigate the ultrasound markers that characterize complex gastroschisis. A systematic review of the literature was conducted according to the guidelines of PRISMA. The protocol was registered (PROSPERO ID CRD42020211685). Meta-analysis was displayed graphically on Forest plots, which estimate prevalence rates and risk ratios, with 95% confidence intervals, using STATA version 15.0. The combined prevalence of intestinal complications in fetuses with complex gastroschisis was 27.0%, with a higher prevalence of atresia (about 48%), followed by necrosis (about 25%). The prevalence of deaths in newborns with complex gastroschisis was 15.0%. The predictive ultrasound markers for complex gastroschisis were intraabdominal bowel dilatation (IABD) (RR 3.01, 95% CI 2.22 to 4.07; I2 = 15.7%), extra-abdominal bowel dilatation (EABD) (RR 1.55, 95% CI 1.01 to 2.39; I2 = 77.1%), and polyhydramnios (RR 3.81, 95% CI 2.09 to 6.95; I2 = 0.0%). This review identified that IABD, EABD, and polyhydramnios were considered predictive ultrasound markers for complex gastroschisis. However, evidence regarding gestational age at the time of diagnosis is needed.
摘要：
虽然腹裂通常通过产前超声诊断，关于产前超声标记物可以预测复杂胃裂的文献仍有空白。本系统综述和荟萃分析旨在研究表征复杂胃裂的超声标志物。根据PRISMA的指南对文献进行了系统回顾。协议已注册（PROSPEROIDCRD42020211685）。荟萃分析在森林地块上以图形方式显示，估计患病率和风险比，95%的置信区间，使用STATA版本15.0。复杂腹裂胎儿肠道并发症的合并患病率为27.0%,闭锁的患病率较高(约48%)，其次是坏死（约25％）。新生儿复杂腹裂的死亡率为15.0%。复杂性腹裂的预测超声标志物为腹内肠扩张(IABD)(RR3.01,95%CI2.22至4.07;I2=15.7%),腹外肠扩张(EABD)(RR1.55,95%CI1.01~2.39;I2=77.1%),和羊水过多（RR3.81，95％CI2.09至6.95；I2=0.0％）。这项审查确定了IABD，EABD,羊水过多被认为是复杂腹裂的预测超声标志物。然而,诊断时需要有关胎龄的证据.
