PDF(Pubmed)
Abstract：
The Chinese medicine monomer cynaroside (Cy) is a flavonoid glycoside compound that widely exists in plants and has a variety of pharmacological effects, such as its important role in the respiratory system, cardiovascular system and central nervous system. Studies have reported that Cy has varying degrees of anticancer activity in non-small cell lung cancer, cervical cancer, liver cancer, esophageal cancer and other cancers. However, there are no relevant reports about its role in gastric cancer. The MET/AKT/mTOR signaling pathway plays important roles in regulating various biological processes, including cell proliferation, apoptosis, autophagy, invasion and tumorigenesis. In this study, we confirmed that Cy can inhibit the cell growth, migration and invasion and tumorigenesis in gastric cancer. Our finding shows that Cy can block the MET/AKT/mTOR axis by decreasing the phosphorylation level of AKT, mTOR and P70S6K. Therefore, the MET/AKT/mTOR axis may be an important target for Cy. In summary, Cy has anti-cancer properties and is expected to be a potential drug for the treatment of gastric cancer.
摘要：
中药单体皂甙(Cy)是一种广泛存在于植物中的黄酮苷类化合物,具有多种药理作用,例如它在呼吸系统中的重要作用，心血管系统和中枢神经系统。有研究报道Cy对非小细胞肺癌有不同程度的抗癌活性,宫颈癌,肝癌,食管癌和其他癌症。然而,关于其在胃癌中的作用尚无相关报道。MET/AKT/mTOR信号通路在调节多种生物过程中发挥着重要作用,包括细胞增殖，凋亡，自噬,侵袭和肿瘤发生。在这项研究中,我们证实Cy可以抑制细胞生长,胃癌的迁移和侵袭与肿瘤发生。我们的发现表明，Cy可以通过降低AKT的磷酸化水平来阻断MET/AKT/mTOR轴，mTOR和P70S6K。因此,MET/AKT/mTOR轴可能是Cy的重要目标。总之,Cy具有抗癌特性，有望成为治疗胃癌的潜在药物。
