PDF(Pubmed)
Abstract：
UNASSIGNED: Solitary fibrous tumours (SFT) are a type of mesenchymal tumour. Whilst the majority of cases follow an indolent course a significant proportion of patients suffer metastases or disease recurrence post-surgical excision. Due to the unpredictable clinical course follow up duration and intensity remains contentious.
UNASSIGNED: We aimed to determine current outcomes of management of this tumour, apply and assess current risk recurrence models to determine if our standard of care could be improved upon.
UNASSIGNED: A prospective database of patients treated at a regional musculoskeletal oncology service was assessed. Only extra-pleural, extra-meningeal SFTs were included in the study. Surgical outcome and post-operative investigations were scrutinised and the Pasquali and Demicco recurrence risk models were applied and assessed.
UNASSIGNED: From 2009 to 2019 12 patients were identified, 8 female and 4 males. Their age at diagnosis ranged from 21 to 76 years. 11 patients underwent surgery with curative intent and no patient suffered disease progression or recurrence, with a mean follow up time of 41 months. One patient presented with metastatic disease and was managed palliatively.
UNASSIGNED: Following this review of our case series and utilising risk recurrence models published in the literature we have changed our follow up protocol. In new cases of SFT the Pasquali prognostic model, with the addition of the presence or absence of necrosis, will be utilised. If a patient has benign features on initial biopsy we propose to not perform staging. Furthermore, if biopsy and final pathology results remain concordant, with no concerning features, and the patient has undergone complete excision reduced intensity follow up could be considered.Level of evidence Level IV, retrospective case series.
UNASSIGNED: We aimed to determine current outcomes of management of this tumour, apply and assess current risk recurrence models to determine if our standard of care could be improved upon.
UNASSIGNED: A prospective database of patients treated at a regional musculoskeletal oncology service was assessed. Only extra-pleural, extra-meningeal SFTs were included in the study. Surgical outcome and post-operative investigations were scrutinised and the Pasquali and Demicco recurrence risk models were applied and assessed.
UNASSIGNED: From 2009 to 2019 12 patients were identified, 8 female and 4 males. Their age at diagnosis ranged from 21 to 76 years. 11 patients underwent surgery with curative intent and no patient suffered disease progression or recurrence, with a mean follow up time of 41 months. One patient presented with metastatic disease and was managed palliatively.
UNASSIGNED: Following this review of our case series and utilising risk recurrence models published in the literature we have changed our follow up protocol. In new cases of SFT the Pasquali prognostic model, with the addition of the presence or absence of necrosis, will be utilised. If a patient has benign features on initial biopsy we propose to not perform staging. Furthermore, if biopsy and final pathology results remain concordant, with no concerning features, and the patient has undergone complete excision reduced intensity follow up could be considered.Level of evidence Level IV, retrospective case series.
摘要：
■孤立性纤维肿瘤(SFT)是间质肿瘤的一种。虽然大多数病例遵循惰性过程，但很大一部分患者在手术切除后遭受转移或疾病复发。由于不可预测的临床过程，随访的持续时间和强度仍然存在争议。
■我们的目标是确定当前治疗这种肿瘤的结果，应用和评估当前的风险复发模型,以确定我们的护理标准是否可以得到改善.
■评估了在区域性肌肉骨骼肿瘤服务机构接受治疗的患者的前瞻性数据库。只有胸膜外,脑膜外SFT纳入研究.仔细检查手术结果和术后检查，并应用并评估Pasquali和Demicco复发风险模型。
■从2009年到2019年，确定了12名患者，8名女性和4名男性。他们的诊断年龄为21至76岁。11例患者接受了治愈性手术，没有患者出现疾病进展或复发，平均随访时间为41个月。一名患者患有转移性疾病，并接受了姑息治疗。
在回顾我们的病例系列并利用文献中发表的风险复发模型之后，我们改变了我们的随访方案。在新的SFT病例中，Pasquali预后模型，加上坏死的存在或不存在，将被利用。如果患者在初次活检时具有良性特征，我们建议不进行分期。此外，如果活检和最终病理结果保持一致，没有相关特征，并且患者已接受完全切除，可以考虑降低强度随访。证据级别IV级,回顾性病例系列。
■我们的目标是确定当前治疗这种肿瘤的结果，应用和评估当前的风险复发模型,以确定我们的护理标准是否可以得到改善.
■评估了在区域性肌肉骨骼肿瘤服务机构接受治疗的患者的前瞻性数据库。只有胸膜外,脑膜外SFT纳入研究.仔细检查手术结果和术后检查，并应用并评估Pasquali和Demicco复发风险模型。
■从2009年到2019年，确定了12名患者，8名女性和4名男性。他们的诊断年龄为21至76岁。11例患者接受了治愈性手术，没有患者出现疾病进展或复发，平均随访时间为41个月。一名患者患有转移性疾病，并接受了姑息治疗。
在回顾我们的病例系列并利用文献中发表的风险复发模型之后，我们改变了我们的随访方案。在新的SFT病例中，Pasquali预后模型，加上坏死的存在或不存在，将被利用。如果患者在初次活检时具有良性特征，我们建议不进行分期。此外，如果活检和最终病理结果保持一致，没有相关特征，并且患者已接受完全切除，可以考虑降低强度随访。证据级别IV级,回顾性病例系列。
