PDF(Pubmed)
Abstract：
UNASSIGNED: Current guidelines recommend a 50 mm or greater compression depth for manual chest compression in adults. However, whether this uniform compression depth is a suitable requirement for mechanical CPR remains to be determined. We hypothesized that a relatively shallow compression depth (30 mm) would have similar hemodynamic efficacy but fewer complications versus the standard compression depth (50 mm) during mechanical cardiopulmonary resuscitation (CPR) with the miniaturized chest compressor (MCC) in a porcine model.
UNASSIGNED: In the current study, we used a total of 16 domestic male pigs (38±2 kg). All pigs were exposed to 7 min of ventricular fibrillation (VF) followed by 5 min of CPR. Then the animals were randomly assigned to the shallow (30 mm) group and the standard (50 mm) group. At the second min of CPR, every pig was given epinephrine (20 µg/kg) through the femoral vein and repeated every 3 min. First defibrillation was delivered with a single 120 J shock at 5 min of CPR. Hemodynamics, carotid blood flow (CBF), end-tidal carbon dioxide (ETCO2), coronary perfusion pressure (CPP), intrathoracic pressure (ITP) and arterial blood gas were measured. Rib fractures and lung injuries, as indicated by ground-glass opacification (GGO), as well as intense parenchymal opacification (IPO), were assessed and calculated by quantitative computed tomography (QCT) scan.
UNASSIGNED: We found no significant differences in CPP, CBF, or ETCO2 between the both groups throughout the CPR period. After administration of epinephrine, the CPP of all animals increased while ETCO2 and CBF decreased during CPR. A significantly lower intrathoracic positive pressure (ITPP) and systolic artery pressure (SAP) were measured in the shallow group at the first min of CPR. However, we didn\'t find remarkable differences in these values between the both groups for the next 4 min of CPR. All animals were successfully resuscitated. The shallow group had significantly lower IPO QCT scores compared with the standard group. We found no significant differences in GGO QCT scores after resuscitation between both groups.
UNASSIGNED: Relatively shallow compression depth has similar hemodynamic efficacy but fewer complications versus the standard compression depth.
UNASSIGNED: In the current study, we used a total of 16 domestic male pigs (38±2 kg). All pigs were exposed to 7 min of ventricular fibrillation (VF) followed by 5 min of CPR. Then the animals were randomly assigned to the shallow (30 mm) group and the standard (50 mm) group. At the second min of CPR, every pig was given epinephrine (20 µg/kg) through the femoral vein and repeated every 3 min. First defibrillation was delivered with a single 120 J shock at 5 min of CPR. Hemodynamics, carotid blood flow (CBF), end-tidal carbon dioxide (ETCO2), coronary perfusion pressure (CPP), intrathoracic pressure (ITP) and arterial blood gas were measured. Rib fractures and lung injuries, as indicated by ground-glass opacification (GGO), as well as intense parenchymal opacification (IPO), were assessed and calculated by quantitative computed tomography (QCT) scan.
UNASSIGNED: We found no significant differences in CPP, CBF, or ETCO2 between the both groups throughout the CPR period. After administration of epinephrine, the CPP of all animals increased while ETCO2 and CBF decreased during CPR. A significantly lower intrathoracic positive pressure (ITPP) and systolic artery pressure (SAP) were measured in the shallow group at the first min of CPR. However, we didn\'t find remarkable differences in these values between the both groups for the next 4 min of CPR. All animals were successfully resuscitated. The shallow group had significantly lower IPO QCT scores compared with the standard group. We found no significant differences in GGO QCT scores after resuscitation between both groups.
UNASSIGNED: Relatively shallow compression depth has similar hemodynamic efficacy but fewer complications versus the standard compression depth.
摘要：
■当前指南建议成人手动胸部按压的按压深度为50毫米或更大。然而,这种均匀的按压深度是否是机械CPR的合适要求仍有待确定。我们假设在猪模型中使用小型胸部按压器（MCC）进行机械心肺复苏（CPR）期间，相对较浅的按压深度（30mm）将具有相似的血液动力学功效，但与标准按压深度（50mm）相比，并发症较少。
■在当前的研究中，我们总共使用了16头家养雄性猪(38±2公斤)。所有猪暴露于7分钟的心室纤颤（VF），然后进行5分钟的CPR。然后将动物随机分配到浅(30mm)组和标准(50mm)组。在心肺复苏的第二分钟，每头猪通过股静脉给予肾上腺素(20µg/kg),每3分钟重复一次.首次除颤在心肺复苏5分钟时进行单次120J电击。血流动力学,颈动脉血流量（CBF），潮气末二氧化碳(ETCO2)，冠状动脉灌注压(CPP),测量胸内压（ITP）和动脉血气。肋骨骨折和肺损伤,如毛玻璃混浊(GGO)所示，以及强烈的实质混浊(IPO)，通过定量计算机断层扫描（QCT）扫描进行评估和计算。
■我们发现CPP没有显着差异，CBF,或在整个CPR期间两组之间的ETCO2。服用肾上腺素后，CPR期间所有动物的CPP均升高，而ETCO2和CBF降低。在CPR的第一分钟，浅组的胸腔内正压（ITPP）和收缩压（SAP）显着降低。然而,在接下来的4分钟的CPR中，我们没有发现两组之间的这些值存在显着差异。所有动物均成功复苏。浅层组的IPOQCT评分明显低于标准组。我们发现两组复苏后GGOQCT评分没有显着差异。
■与标准按压深度相比，较浅按压深度具有相似的血流动力学功效，但并发症较少。
■在当前的研究中，我们总共使用了16头家养雄性猪(38±2公斤)。所有猪暴露于7分钟的心室纤颤（VF），然后进行5分钟的CPR。然后将动物随机分配到浅(30mm)组和标准(50mm)组。在心肺复苏的第二分钟，每头猪通过股静脉给予肾上腺素(20µg/kg),每3分钟重复一次.首次除颤在心肺复苏5分钟时进行单次120J电击。血流动力学,颈动脉血流量（CBF），潮气末二氧化碳(ETCO2)，冠状动脉灌注压(CPP),测量胸内压（ITP）和动脉血气。肋骨骨折和肺损伤,如毛玻璃混浊(GGO)所示，以及强烈的实质混浊(IPO)，通过定量计算机断层扫描（QCT）扫描进行评估和计算。
■我们发现CPP没有显着差异，CBF,或在整个CPR期间两组之间的ETCO2。服用肾上腺素后，CPR期间所有动物的CPP均升高，而ETCO2和CBF降低。在CPR的第一分钟，浅组的胸腔内正压（ITPP）和收缩压（SAP）显着降低。然而,在接下来的4分钟的CPR中，我们没有发现两组之间的这些值存在显着差异。所有动物均成功复苏。浅层组的IPOQCT评分明显低于标准组。我们发现两组复苏后GGOQCT评分没有显着差异。
■与标准按压深度相比，较浅按压深度具有相似的血流动力学功效，但并发症较少。
