PDF(Pubmed)
Abstract：
Growth references are traditionally constructed relative to chronological age, despite inter-individual variations in pubertal timing. A new type of height reference was recently developed allowing growth to be aligned based on onset of pubertal height growth. We here aim to develop a corresponding reference for pubertal weight.
To model QEPS-weight, 3595 subjects (1779 girls) from GrowUp1974Gothenburg and GrowUp1990Gothenburg were used. The QEPS-height-model was transformed to a corresponding QEPS-weight-model; thereafter, QEPS-weight was modified by an individual, constitutional weight-height-factor. Longitudinal weight and length/height measurements from 1418 individuals (698 girls) from GrowUp1990Gothenburg were then used to create weight references aligned for height at pubertal onset (the age at 5% of P-function growth, AgeP5). GrowUp1974Gothenburg subgroups based on pubertal timing, stature at pubertal onset, and childhood body composition were assessed using the references.
References (median, SDS) for total weight (QEPS-functions), weight specific to puberty (P-function), and weight gain in the absence of specific pubertal growth (basic weight, QES-functions), allowing alignment of individual growth based on age at pubertal onset. For both sexes, basic weight was greater than average for late maturing, tall and high-BMI subgroups. The P-function-related weight was greater than average in short and lower than average in tall children, in those with high BMI, and in girls but not boys with low BMI.
New pubertal weight references allow individual variations in pubertal timing to be taken into consideration when evaluating growth. When used together with the comparable pubertal height reference, this will improve growth monitoring in clinical practice for identifying abnormal growth and serve as a valuable research tool providing insight into human growth.
To model QEPS-weight, 3595 subjects (1779 girls) from GrowUp1974Gothenburg and GrowUp1990Gothenburg were used. The QEPS-height-model was transformed to a corresponding QEPS-weight-model; thereafter, QEPS-weight was modified by an individual, constitutional weight-height-factor. Longitudinal weight and length/height measurements from 1418 individuals (698 girls) from GrowUp1990Gothenburg were then used to create weight references aligned for height at pubertal onset (the age at 5% of P-function growth, AgeP5). GrowUp1974Gothenburg subgroups based on pubertal timing, stature at pubertal onset, and childhood body composition were assessed using the references.
References (median, SDS) for total weight (QEPS-functions), weight specific to puberty (P-function), and weight gain in the absence of specific pubertal growth (basic weight, QES-functions), allowing alignment of individual growth based on age at pubertal onset. For both sexes, basic weight was greater than average for late maturing, tall and high-BMI subgroups. The P-function-related weight was greater than average in short and lower than average in tall children, in those with high BMI, and in girls but not boys with low BMI.
New pubertal weight references allow individual variations in pubertal timing to be taken into consideration when evaluating growth. When used together with the comparable pubertal height reference, this will improve growth monitoring in clinical practice for identifying abnormal growth and serve as a valuable research tool providing insight into human growth.
摘要：
生长参考传统上是相对于实际年龄构建的，尽管青春期时间的个体差异。最近开发了一种新型的身高参考，允许根据青春期身高增长的开始来对齐增长。我们在这里旨在为青春期体重开发相应的参考。
要对QEPS重量进行建模，使用了GrowUp1974Gothenburg和GrowUp1990Gothenburg的3595名受试者（1779名女孩）。将QEPS身高模型转换为相应的QEPS体重模型；然后，QEPS重量由个人修改，体质身高因素。然后使用GrowUp1990哥德堡的1418名个体（698名女孩）的纵向体重和身高测量结果来创建与青春期开始时身高对齐的体重参考（P功能增长5％的年龄，AgeP5）。GrowUp1974Gothenburg亚组基于青春期时间，青春期开始时的身材，和儿童身体成分使用参考进行评估。
参考(中位数，SDS)总重量(QEPS函数)，青春期特定的体重（P功能），在没有特定青春期生长的情况下体重增加(基本体重，QES-功能)，允许根据青春期开始时的年龄排列个体生长。对两性来说，晚熟的基本重量大于平均水平，高和高BMI亚组。与P功能相关的体重在矮小儿童中大于平均值，而在高个子儿童中低于平均值。在那些高BMI的人中，和女孩，但不是低BMI的男孩。
新的青春期体重参考允许在评估生长时考虑青春期时间的个体差异。当与可比较的青春期身高参考一起使用时，这将改善临床实践中的生长监测，以识别异常生长，并作为一个有价值的研究工具，提供对人类生长的洞察力。
要对QEPS重量进行建模，使用了GrowUp1974Gothenburg和GrowUp1990Gothenburg的3595名受试者（1779名女孩）。将QEPS身高模型转换为相应的QEPS体重模型；然后，QEPS重量由个人修改，体质身高因素。然后使用GrowUp1990哥德堡的1418名个体（698名女孩）的纵向体重和身高测量结果来创建与青春期开始时身高对齐的体重参考（P功能增长5％的年龄，AgeP5）。GrowUp1974Gothenburg亚组基于青春期时间，青春期开始时的身材，和儿童身体成分使用参考进行评估。
参考(中位数，SDS)总重量(QEPS函数)，青春期特定的体重（P功能），在没有特定青春期生长的情况下体重增加(基本体重，QES-功能)，允许根据青春期开始时的年龄排列个体生长。对两性来说，晚熟的基本重量大于平均水平，高和高BMI亚组。与P功能相关的体重在矮小儿童中大于平均值，而在高个子儿童中低于平均值。在那些高BMI的人中，和女孩，但不是低BMI的男孩。
新的青春期体重参考允许在评估生长时考虑青春期时间的个体差异。当与可比较的青春期身高参考一起使用时，这将改善临床实践中的生长监测，以识别异常生长，并作为一个有价值的研究工具，提供对人类生长的洞察力。
