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Abstract：
OBJECTIVE: To evaluate the relationship between serum Gd-IgA1 (sGd-IgA1) and serum and urine TNFR1 (sTNFR1, uTNFR1) levels as possible prognostic factors in IgA nephropathy (IgAN) and IgA vasculitis nephritis (IgAVN).
METHODS: From 299 patients from the Polish Registry of Pediatric IgAN and IgAVN, 60 children (24 IgAN and 36 IgAVN) were included in the study. The control group consisted of 20 healthy children. Proteinuria, haematuria, serum creatinine as well as IgA and C3 levels were measured and glomerular filtration rate (GFR) was calculated at onset and at the end of the follow-up. Kidney biopsy findings were evaluated using the Oxford classification. Serum Gd-IgA1 and serum and urine TNFR1 levels were measured at the end of follow-up.
RESULTS: Serum Gd-IgA1 level was significantly higher in IgAN and IgAVN patients in comparison to the control group. Urine TNFR1 was significantly higher in IgAN than in IgAVN and the control group. We did not observe any differences in sTNFR1 level between IgAN, IgAVN and control groups. We found a positive correlation between Gd-IgA1 and creatinine (r = 0.34), and negative between Gd-IgA1 and GFR (r = -0.35) at the end of follow-up. We observed a negative correlation between uTNFR1/creatinine log and albumin level and protein/creatinine ratio. We did not find any correlations between Gd-IgA1 and TNFR1.
CONCLUSIONS: The prognostic value of sGd-IgA1 in children with IgAN and IgAVN has been confirmed. TNFR1 is not associated with Gd-IgA1 and is not a useful prognostic marker in children with IgAN/IgAVN and normal kidney function.
METHODS: From 299 patients from the Polish Registry of Pediatric IgAN and IgAVN, 60 children (24 IgAN and 36 IgAVN) were included in the study. The control group consisted of 20 healthy children. Proteinuria, haematuria, serum creatinine as well as IgA and C3 levels were measured and glomerular filtration rate (GFR) was calculated at onset and at the end of the follow-up. Kidney biopsy findings were evaluated using the Oxford classification. Serum Gd-IgA1 and serum and urine TNFR1 levels were measured at the end of follow-up.
RESULTS: Serum Gd-IgA1 level was significantly higher in IgAN and IgAVN patients in comparison to the control group. Urine TNFR1 was significantly higher in IgAN than in IgAVN and the control group. We did not observe any differences in sTNFR1 level between IgAN, IgAVN and control groups. We found a positive correlation between Gd-IgA1 and creatinine (r = 0.34), and negative between Gd-IgA1 and GFR (r = -0.35) at the end of follow-up. We observed a negative correlation between uTNFR1/creatinine log and albumin level and protein/creatinine ratio. We did not find any correlations between Gd-IgA1 and TNFR1.
CONCLUSIONS: The prognostic value of sGd-IgA1 in children with IgAN and IgAVN has been confirmed. TNFR1 is not associated with Gd-IgA1 and is not a useful prognostic marker in children with IgAN/IgAVN and normal kidney function.
摘要：
目的：评价血清Gd-IgA1(sGd-IgA1)与血清及尿TNFR1(sTNFR1、uTNFR1)水平作为IgA肾病(IgAN)和IgA血管炎性肾炎(IgAVN)可能的预后因素的关系。
方法：来自波兰儿科IgAN和IgAVN注册中心的299例患者，60名儿童（24名IgAN和36名IgAVN）被纳入研究。对照组为20名健康儿童。蛋白尿,血尿,在随访开始和结束时测量血清肌酐以及IgA和C3水平,并计算肾小球滤过率(GFR).使用牛津分类评估肾活检结果。随访结束时测定血清Gd-IgA1、血清和尿TNFR1水平。
结果：与对照组相比，IgAN和IgAVN患者的血清Gd-IgA1水平明显升高。IgAN中的尿TNFR1明显高于IgAVN和对照组。我们没有观察到IgAN之间sTNFR1水平的任何差异，IgAVN和对照组。Gd-IgA1与肌酐呈正相关(r=0.34),随访结束时Gd-IgA1和GFR之间为阴性（r=-0.35）。我们观察到uTNFR1/肌酐对数与白蛋白水平和蛋白质/肌酐比值之间呈负相关。我们没有发现Gd-IgA1和TNFR1之间的任何相关性。
结论：已经证实了sGd-IgA1在IgAN和IgAVN患儿中的预后价值。TNFR1与Gd-IgA1无关，并且在具有IgAN/IgAVN和正常肾功能的儿童中不是有用的预后标志物。
方法：来自波兰儿科IgAN和IgAVN注册中心的299例患者，60名儿童（24名IgAN和36名IgAVN）被纳入研究。对照组为20名健康儿童。蛋白尿,血尿,在随访开始和结束时测量血清肌酐以及IgA和C3水平,并计算肾小球滤过率(GFR).使用牛津分类评估肾活检结果。随访结束时测定血清Gd-IgA1、血清和尿TNFR1水平。
结果：与对照组相比，IgAN和IgAVN患者的血清Gd-IgA1水平明显升高。IgAN中的尿TNFR1明显高于IgAVN和对照组。我们没有观察到IgAN之间sTNFR1水平的任何差异，IgAVN和对照组。Gd-IgA1与肌酐呈正相关(r=0.34),随访结束时Gd-IgA1和GFR之间为阴性（r=-0.35）。我们观察到uTNFR1/肌酐对数与白蛋白水平和蛋白质/肌酐比值之间呈负相关。我们没有发现Gd-IgA1和TNFR1之间的任何相关性。
结论：已经证实了sGd-IgA1在IgAN和IgAVN患儿中的预后价值。TNFR1与Gd-IgA1无关，并且在具有IgAN/IgAVN和正常肾功能的儿童中不是有用的预后标志物。
