PDF(Pubmed)
Abstract：
The consumption of linoleic acid (LA, ω-6 18:2), the most common ω-6 polyunsaturated fatty acid (PUFA) in the Modern Western diet (MWD), has significantly increased over the last century in tandem with unprecedented incidence of chronic metabolic diseases like obesity and type 2 diabetes mellitus (T2DM). Although an essential fatty acid for health, LA was a very rare fatty acid in the diet of humans during their evolution. While the intake of other dietary macronutrients (carbohydrates like fructose) has also risen, diets rich in ω-6 PUFAs have been promoted in an effort to reduce cardiovascular disease despite unclear evidence as to how increased dietary LA consumption could promote a proinflammatory state and affect glucose metabolism. Current evidence suggests that sex, genetics, environmental factors, and disease status can differentially modulate how LA influences insulin sensitivity and peripheral glucose uptake as well as insulin secretion and pancreatic beta-cell function. Therefore, the aim of this review will be to summarize recent additions to our knowledge to refine the unique physiological and pathophysiological roles of LA in the regulation of glucose homeostasis.
摘要：
亚油酸的消耗(LA，ω-618:2)，现代西方饮食（MWD）中最常见的ω-6多不饱和脂肪酸（PUFA），在过去的一个世纪中，肥胖和2型糖尿病（T2DM）等慢性代谢性疾病的发病率空前增加。虽然是健康的必需脂肪酸，在人类进化过程中，LA是一种非常罕见的脂肪酸。虽然其他膳食常量营养素（碳水化合物如果糖）的摄入量也有所增加，富含ω-6PUFA的饮食已被推广以努力减少心血管疾病,尽管关于增加饮食LA消耗如何促进促炎状态和影响葡萄糖代谢的证据不清楚.目前的证据表明性,遗传学,环境因素,和疾病状态可以差异调节LA如何影响胰岛素敏感性和外周葡萄糖摄取以及胰岛素分泌和胰腺β细胞功能。因此,这篇综述的目的是总结我们最近增加的知识，以完善LA在调节葡萄糖稳态中的独特生理和病理生理作用。
