METHODS: Forty-four cases with minor salivary gland carcinoma who underwent both primary resection and neck dissection were retrospectively enrolled. The pathological continuous variables were evaluated by the number of positive lymph nodes, lymph node ratio, and log odds of positive lymph nodes. Receiver operating curve analysis was used for the cut-off values of the carcinoma-specific death. Log-rank test and Cox\'s proportional hazards model were used for uni-/multi-variate survival analyses adjusting for pathological stage, respectively.
RESULTS: Lymph node ratio = 0.05 as well as log odds of positive lymph nodes = - 2.73 predicted the carcinoma-specific death. Both lymph node ratio and log odds of positive lymph nodes were significantly related with survival outcomes by the univariate analysis. Lymph node ratio ≥ 0.05 was associated with shorter disease-specific (hazard ratio = 7.90, 95% confidence interval = 1.54-57.1), disease-free (hazard ratio = 4.15, 95% confidence interval = 1.48-11.2) and overall (hazard ratio = 4.84, 95% confidence interval = 1.05-24.8) survival in the multivariate analysis.
CONCLUSIONS: A higher lymph node ratio of minor salivary gland carcinoma is a predictor of shorter survival results.
方法:回顾性研究了44例小唾液腺癌同时进行了原发切除和颈清扫术的患者。通过阳性淋巴结的数量评估病理连续变量,淋巴结比率,并记录淋巴结阳性的几率。受试者工作曲线分析用于癌特异性死亡的截止值。使用Log-rank检验和Cox's比例风险模型进行单/多变量生存分析,调整病理分期,分别。
结果:淋巴结比率=0.05以及阳性淋巴结的对数几率=-2.73预测了癌症特异性死亡。通过单因素分析,淋巴结比率和阳性淋巴结的对数几率与生存结果显着相关。淋巴结比率≥0.05与较短的疾病特异性相关(风险比=7.90,95%置信区间=1.54-57.1)。多变量分析中的无病生存(风险比=4.15,95%置信区间=1.48-11.2)和总体生存(风险比=4.84,95%置信区间=1.05-24.8).
结论:小唾液腺癌的较高淋巴结比率是较短生存结果的预测因子。