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Abstract：
Background: Crosstalk of circular RNAs (circRNAs) and microRNAs (miRNAs) refers to the communication and co-regulation between them. circRNAs can act as miRNAs sponges, and miRNAs can mediate circRNAs. They interact to regulate gene expression and participate in the occurrence and development of various human diseases. Methods: Publications on the crosstalk between miRNAs and circRNAs in human diseases were collected from Web of Science. The collected material was limited to English articles and reviews. CiteSpace and Microsoft Excel were used for bibliographic analysis. Results: A total of 1,013 papers satisfied the inclusion criteria. The publication outputs and types of researched diseases were analyzed, and bibliographic analysis was used to characterize the most active journals, countries, institutions, keywords, and references. The annual number of publications remarkably increased from 2011 to 2020. Neoplasm was the main research hotspot (n = 750 publications), and Biochemical and Biophysical Research Communications published the largest number of papers (n = 64) on this topic. Nanjing Medical University ranked first among institutions actively engaged in this field by publishing 72 papers, and China contributed 96.84% of the 1,013 papers (n = 981 publications) analyzed. Burst keywords in recent years included glioblastoma, miR-7, skeletal muscle, and non-coding RNA. Conclusion: Crosstalk between miRNAs and circRNAs in human diseases is a popular research topic. This study provides important clues on research trends and frontiers.
摘要：
背景：环状RNA（circRNAs）和微小RNA（miRNA）的串扰是指它们之间的通讯和共同调节。circRNAs可以充当miRNAs海绵，和miRNA可以介导circRNAs。它们相互作用调节基因表达,参与人类各种疾病的发生和发展。方法：从WebofScience收集了有关人类疾病中miRNA和circRNAs之间的串扰的出版物。收集的材料仅限于英文文章和评论。使用CiteSpace和MicrosoftExcel进行书目分析。结果：共有1,013篇论文符合纳入标准。分析了研究疾病的出版物输出和类型，书目分析被用来描述最活跃的期刊，国家,机构,关键词,和参考。从2011年到2020年，出版物的年度数量显着增加。肿瘤是主要的研究热点(n=750)，生物化学和生物物理研究通讯发表了关于这一主题的论文数量最多（n=64）。南京医科大学通过发表72篇论文，在积极参与该领域的机构中排名第一，在分析的1013篇论文(n=981篇出版物)中，中国贡献了96.84%。近年来的爆发关键词包括胶质母细胞瘤，miR-7，骨骼肌，和非编码RNA。结论：miRNAs与circRNAs之间的串扰是人类疾病研究的热门课题。本研究为研究趋势和前沿提供了重要线索。
