Abstract：
The HES proteins (hairy and Enhancer of split (E(spl)) homologs) are basic helix-loop-helix (bHLH) transcription factors that regulate the proliferation and differentiation of stem cells. Family members HES1, 3, and 5 are all critical regulators of nervous system development. The Hes genes exhibit oscillatory expression levels, and this dynamic expression allows for the complex regulation of numerous downstream genes such as Ascl1, Neurog2, Olig2 involved in the differentiation of specific cell types. In addition, HES proteins act as hubs for the molecule crosstalk among Notch, Wnt, and other signaling pathways that regulate nervous system development.
摘要：
HES蛋白(毛状和分裂增强子(E(spl))同源物)是调节干细胞增殖和分化的基本螺旋-环-螺旋(bHLH)转录因子。家族成员HES1、3和5都是神经系统发育的关键调节因子。Hes基因表现出振荡表达水平，并且这种动态表达允许复杂调节许多下游基因，例如参与特定细胞类型分化的Ascl1，Neurog2，Olig2。此外,HES蛋白充当Notch之间分子串扰的枢纽，Wnt,和其他调节神经系统发育的信号通路。
