Abstract：
Refractory wounds present a complex and serious clinical dilemma in plastic and reconstructive surgery. However, there are currently no standard guidelines for the treatment of refractory wounds. Artificial dermis (AD) has achieved some satisfactory results, but also has some limitations. Autologous platelet-rich plasma (PRP), as a cell-therapy material, was a valuable and safe treatment dressing for chronic non-healing wounds. This study aimed to evaluate the efficacies of artificial dermis (AD) with and without autologous platelet-rich plasma (PRP) in patients with refractory wounds. Sixteen patients with refractory wounds were randomly allocated to autologous PRP therapy combined with artificial dermis (PRP + AD [N = 8]) or an artificial dermis program only (AD [N = 8]). We compared the efficacies of the two methods in terms of times to wound healing, infection control, and AD vascularization, as well as hospitalization days and eventual clinical outcomes.13 patients achieved complete healing, including seven (87.5%) in the PRP + AD group and six (75.0%) in the AD group (P > .05). The times to wound healing, infection control, and AD vascularization, and hospitalization time after transfer were significantly shorter in the PRP + AD group compared with the AD group (P < .05). In conclusion, the combination of AD and PRP promoted refractory wound healing and shortened waiting times compared with simple dermal grafts.
摘要：
难治性伤口在整形和重建手术中呈现出复杂而严重的临床困境。然而,目前尚无治疗难治性伤口的标准指南。人工真皮(AD)取得了满意的效果,但也有一些局限性。自体富血小板血浆(PRP),作为细胞治疗材料，是一种有价值和安全的慢性不愈合伤口的治疗敷料。这项研究旨在评估有和没有自体富血小板血浆（PRP）的人造真皮（AD）在难治性伤口患者中的疗效。16例难治性伤口患者被随机分配到自体PRP治疗联合人工真皮（PRPAD[N=8]）或仅人工真皮计划（AD[N=8]）。我们比较了两种方法在伤口愈合时间方面的效果，感染控制,和AD血管化，以及住院天数和最终的临床结果.13例患者获得完全愈合,其中PRP+AD组7人(87.5%),AD组6人(75.0%)(P>.05)。伤口愈合的时代，感染控制,和AD血管化，转院后PRP+AD组住院时间明显短于AD组（P<0.05）。总之,与单纯真皮移植相比,AD和PRP联合应用可促进难治性创面愈合并缩短等待时间.
