PDF(Pubmed)
Abstract：
Peripheral nerve injury often occurs in young adults and is characterized by complex regeneration mechanisms, poor prognosis, and slow recovery, which not only creates psychological obstacles for the patients but also causes a significant burden on society, making it a fundamental problem in clinical medicine. Various steps are needed to promote regeneration of the peripheral nerve. As a bioremediation material, self-assembled peptide (SAP) hydrogels have attracted international attention. They can not only be designed with different characteristics but also be applied in the repair of peripheral nerve injury by promoting cell proliferation or drug-loaded sustained release. SAP hydrogels are widely used in tissue engineering and have become the focus of research. They have extensive application prospects and are of great potential biological value. In this paper, the application of SAP hydrogel in peripheral nerve injury repair is reviewed, and the latest progress in peptide composites and fabrication techniques are discussed.
摘要：
周围神经损伤常发生在青壮年，其特征是复杂的再生机制，预后不良,和缓慢的恢复，这不仅给患者造成心理障碍，而且给社会带来巨大负担，使其成为临床医学中的一个基本问题。需要各种步骤来促进外周神经的再生。作为一种生物修复材料,自组装肽(SAP)水凝胶已引起国际关注。它们不仅可以设计具有不同的特性，而且可以通过促进细胞增殖或载药缓释来修复周围神经损伤。SAP水凝胶在组织工程中有着广泛的应用,已成为研究的热点。它们具有广泛的应用前景，具有巨大的潜在生物学价值。在本文中,综述了SAP水凝胶在周围神经损伤修复中的应用,并讨论了肽复合材料和制备技术的最新进展。
