PDF(Pubmed)
Abstract：
Disruption of age-related processes seems to play a relevant role in health effects related to night shift (NS) work. We aim to verify whether NS work can influence biological age (BA), estimated through Zbieć-Piekarska\'s epigenetic signature, based on methylation of five CpG sites in ELOVL2, C1orf132/MIR29B2C, TRIM59, KLF14, and FHL2. Forty-six female nurses working in NS were matched by age and length of employment with 51 female colleagues not working in NS. Each subject filled in a questionnaire (including the Effort Reward Imbalance (ERI) index to assess job stress) and gave a blood sample. Age acceleration (AA) was estimated by regressing BA on chronological age and taking the residuals. Multivariate linear regression models were applied. BA was not associated with NS. However, we did observe an increase in AA per each year in NS in subjects with overweight/obesity (β = 0.46, 95% CI: 0.05; 0.87, p = 0.03), experiencing work-related stress (β = 0.58, 95% CI: 0.10; 1.06, p = 0.018), or both (β = 0.66, 95% CI: 0.03; 1.29, p = 0.041). Although based on a small sample size, our findings suggest an increased BA only among hypersusceptible subjects and is worth further investigation, also in light of recent results suggesting a higher breast cancer risk in women with increased AA.
摘要：
与年龄有关的过程的中断似乎在与夜班（NS）工作有关的健康影响中起着相关作用。我们的目的是验证NS工作是否会影响生物年龄(BA)，通过Zbieć-Piekarska的表观遗传签名估计，基于ELOVL2，C1orf132/MIR29B2C中五个CpG位点的甲基化，TRIM59、KLF14和FHL2。在NS工作的46名女护士的年龄和工作年限与51名不在NS工作的女同事相匹配。每位受试者填写问卷（包括评估工作压力的努力奖励失衡（ERI）指数）并提供血液样本。年龄加速度（AA）是通过将BA与实际年龄进行回归并获取残差来估计的。采用多元线性回归模型。BA与NS无关。然而,我们确实观察到超重/肥胖受试者NS中AA每年增加(β=0.46,95%CI:0.05;0.87,p=0.03),经历与工作相关的压力(β=0.58，95%CI：0.10；1.06，p=0.018)，或两者兼有（β=0.66，95%CI：0.03；1.29，p=0.041）。尽管基于小样本量，我们的研究结果表明，仅在高易感受试者中BA升高，值得进一步调查，此外，鉴于最近的结果表明，AA升高的女性患乳腺癌的风险更高。
