PDF(Pubmed)
Abstract：
BACKGROUND: Alcohol-based hand sanitizers (ABHS) are widely used for hand hygiene due to the coronavirus disease pandemic. However, risk awareness regarding its adverse effects is lacking. We aim to report a case of ocular chemical burn that showed severe clinical presentation associated with ABHS.
METHODS: A 5-year-old girl presented with severe left eye pain after 62% gel-type ABHS splashed into her eye.
METHODS: On slit lamp examination, a near total corneal and conjunctival epithelial defect with limbal pale on the lower half of the cornea was noted. Severe ocular burn by ABHS was prominent with suspected limbal stem cell damage.
METHODS: She was hospitalized and was prescribed topical medications including antibiotics, steroid eye drops with preservative-free artificial tears, and oral nonsteroidal anti-inflammatory drugs.
RESULTS: Despite intensive medical treatments, the corneal and conjunctival epithelial defects showed no improvement up to the 4th hospital day. After additional instillation of autoserum eye drops to promote epithelial healing, the corneal epithelium barely recovered from the temporal limbus. On the third week of admission, the epithelial defect was completely resolved without corneal opacity, although with minimal symblepharon in the lower fornix.
CONCLUSIONS: Gel-type ABHS can cause severe form of ocular chemical burn such as delayed ocular surface healing. In clinical setting, immediate and thorough rinsing of alcohol-based gel and early intensive treatment are crucial.
METHODS: A 5-year-old girl presented with severe left eye pain after 62% gel-type ABHS splashed into her eye.
METHODS: On slit lamp examination, a near total corneal and conjunctival epithelial defect with limbal pale on the lower half of the cornea was noted. Severe ocular burn by ABHS was prominent with suspected limbal stem cell damage.
METHODS: She was hospitalized and was prescribed topical medications including antibiotics, steroid eye drops with preservative-free artificial tears, and oral nonsteroidal anti-inflammatory drugs.
RESULTS: Despite intensive medical treatments, the corneal and conjunctival epithelial defects showed no improvement up to the 4th hospital day. After additional instillation of autoserum eye drops to promote epithelial healing, the corneal epithelium barely recovered from the temporal limbus. On the third week of admission, the epithelial defect was completely resolved without corneal opacity, although with minimal symblepharon in the lower fornix.
CONCLUSIONS: Gel-type ABHS can cause severe form of ocular chemical burn such as delayed ocular surface healing. In clinical setting, immediate and thorough rinsing of alcohol-based gel and early intensive treatment are crucial.
摘要：
背景：由于冠状病毒病的流行，基于酒精的洗手液（ABHS）被广泛用于手部卫生。然而,缺乏对其不利影响的风险意识。我们的目的是报告一例眼部化学烧伤，表现出与ABHS相关的严重临床表现。
方法：一名5岁女孩在62%的凝胶型ABHS溅入眼睛后出现严重的左眼疼痛。
方法：关于裂隙灯检查，观察到几乎完全的角膜和结膜上皮缺损，角膜缘在角膜下半部苍白。ABHS引起的严重眼部烧伤突出，怀疑有角膜缘干细胞损伤。
方法：她住院了，开了包括抗生素在内的局部用药，类固醇滴眼液与无防腐剂的人工泪液，和口服非甾体抗炎药。
结果：尽管进行了大量的医疗治疗，角膜和结膜上皮缺损至第4天无改善.在额外滴注自体血清滴眼液以促进上皮愈合后，角膜上皮几乎没有从颞缘恢复。在入学的第三周，上皮缺损完全解决，无角膜混浊，尽管在下穹窿中具有最小的同音。
结论：凝胶型ABHS可引起严重的眼部化学烧伤，如眼表愈合延迟。在临床环境中，立即彻底冲洗酒精凝胶和早期强化治疗至关重要。
方法：一名5岁女孩在62%的凝胶型ABHS溅入眼睛后出现严重的左眼疼痛。
方法：关于裂隙灯检查，观察到几乎完全的角膜和结膜上皮缺损，角膜缘在角膜下半部苍白。ABHS引起的严重眼部烧伤突出，怀疑有角膜缘干细胞损伤。
方法：她住院了，开了包括抗生素在内的局部用药，类固醇滴眼液与无防腐剂的人工泪液，和口服非甾体抗炎药。
结果：尽管进行了大量的医疗治疗，角膜和结膜上皮缺损至第4天无改善.在额外滴注自体血清滴眼液以促进上皮愈合后，角膜上皮几乎没有从颞缘恢复。在入学的第三周，上皮缺损完全解决，无角膜混浊，尽管在下穹窿中具有最小的同音。
结论：凝胶型ABHS可引起严重的眼部化学烧伤，如眼表愈合延迟。在临床环境中，立即彻底冲洗酒精凝胶和早期强化治疗至关重要。
