PDF(Pubmed)
Abstract：
From the World Health Organization\'s global TB report for 2020, it is estimated that in 2019 at least 80,000 children (a particularly vulnerable population) developed tuberculous meningitis (TBM)-an invariably fatal disease if untreated-although this is likely an underestimate. As our latest technologies have evolved-with the unprecedented development of the various \"omics\" disciplines-a mountain of new data on infectious diseases have been created. However, our knowledge and understanding of infectious diseases are still trying to keep pace. Metabolites offer much biological information, but the insights they permit can be difficult to derive. This review summarizes current metabolomics studies on cerebrospinal fluid (CSF) from TBM cases and collates the metabolic data reported. Collectively, CSF metabolomics studies have identified five classes of metabolites that characterize TBM: amino acids, organic acids, nucleotides, carbohydrates, and \"other\". Taken holistically, the information given in this review serves to promote the mechanistic action of hypothesis generation that will drive and direct future studies on TBM.
摘要：
根据世界卫生组织的2020年全球结核病报告，据估计，2019年至少有80,000名儿童（特别脆弱的人群）患上了结核性脑膜炎（TBM），如果不治疗，这是一种致命的疾病，尽管这可能被低估了。随着我们最新技术的发展，随着各种“组学”学科的空前发展，已经创造了大量关于传染病的新数据。然而,我们对传染病的认识和理解仍在努力跟上。代谢物提供了许多生物学信息，但是他们允许的见解可能很难获得。这篇综述总结了当前来自TBM病例的脑脊液（CSF）的代谢组学研究，并整理了报告的代谢数据。总的来说，CSF代谢组学研究已经确定了表征TBM的五类代谢物：氨基酸，有机酸,核苷酸,碳水化合物,和“其他”。从整体上看，本综述中提供的信息有助于促进假设生成的机械作用，这将推动和指导未来的TBM研究。
