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Abstract：
The primary objective of this study was to determine, using population-based data, whether the addition of postoperative radiotherapy (RT) provides an overall survival benefit in patients with early primary squamous cell carcinoma (SCC) of tongue. The study included the data of tongue cancer patients treated between January 2016 and July 2019 retrieved from our hospital database. Tumours limited to pathologic T1 and T2 category managed with primary surgery with or without postoperative external beam RT were included. Overall survival (OS) and disease-free survival (DFS) were the main outcomes of interest. A total of 211 cases of oral cancer were evaluated and all the patients had clear surgical and pathological margins. Postoperative adjuvant therapy (PORT) was received by 16 patients. Comparison of DFS and OS at 2-year follow-up depicted a similar outcome (p = 0.582 and p = 0.312 respectively). Findings from our study suggest that in the absence of any absolute advantage on quantifiable survival and disease control, it is necessary to define stringent criteria when advocating PORT in early tongue cancer.
摘要：
这项研究的主要目的是确定，使用基于人口的数据，对于早期原发性舌鳞状细胞癌(SCC)患者,是否增加术后放疗(RT)可带来总体生存获益.该研究包括从我们医院数据库检索的2016年1月至2019年7月期间接受治疗的舌癌患者的数据。包括仅限于病理T1和T2类别的肿瘤，可进行或不进行术后外束RT的初次手术。总生存期（OS）和无病生存期（DFS）是感兴趣的主要结果。共评估了211例口腔癌患者，所有患者均有明确的手术和病理切缘。16例患者接受了术后辅助治疗（PORT）。2年随访时DFS和OS的比较显示了相似的结果（分别为p=0.582和p=0.312）。我们的研究结果表明，在可量化的生存和疾病控制方面没有任何绝对优势的情况下，在早期舌癌中提倡PORT时，有必要定义严格的标准。
