PDF(Pubmed)
Abstract：
OBJECTIVE: This study was intended to evaluate the effects of gangliosides combined with mouse nerve growth factor (NGF) on the expression of serum hypoxia-inducible factor-1α (HIF-1α), neuron-specific enolase (NSE), and soluble intercellular adhesion molecule-1 (sICAM-1) levels in neonates with ischemic-hypoxic encephalopathy (HIE).
METHODS: One hundred and thirty neonates with HIE admitted to our hospital from May 2017 to April 2019 were grouped into two groups according to the protocol of a randomized controlled trial, with 65 cases in each group. The control group received ganglioside treatment, while the combined group was treated with ganglioside + NGF for 2 weeks.
RESULTS: The total effective rate of treatment was higher in the combined group (90.77%) than in the control group (76.92%). The recovery time of sucking, consciousness, muscle tone and primitive reflexes was shorter in the combined group than in the control group, and the incidence of neurological sequelae was lower after 1 year in the combined group (4.62%) than in the control group (15.38%) (P < 0.05).
CONCLUSIONS: Gangliosides combined with NGF can promote the recovery of muscle tone and reduce neurological sequelae, which may possibly be achieved by repairing damaged neuronal cells, enhancing antioxidant enzyme activity, and promoting the regression of inflammation.
METHODS: One hundred and thirty neonates with HIE admitted to our hospital from May 2017 to April 2019 were grouped into two groups according to the protocol of a randomized controlled trial, with 65 cases in each group. The control group received ganglioside treatment, while the combined group was treated with ganglioside + NGF for 2 weeks.
RESULTS: The total effective rate of treatment was higher in the combined group (90.77%) than in the control group (76.92%). The recovery time of sucking, consciousness, muscle tone and primitive reflexes was shorter in the combined group than in the control group, and the incidence of neurological sequelae was lower after 1 year in the combined group (4.62%) than in the control group (15.38%) (P < 0.05).
CONCLUSIONS: Gangliosides combined with NGF can promote the recovery of muscle tone and reduce neurological sequelae, which may possibly be achieved by repairing damaged neuronal cells, enhancing antioxidant enzyme activity, and promoting the regression of inflammation.
摘要：
目的：本研究旨在研究神经节苷脂联合鼠神经生长因子（NGF）对血清缺氧诱导因子-1α（HIF-1α）表达的影响。神经元特异性烯醇化酶（NSE），和可溶性细胞间粘附分子-1（sICAM-1）水平在新生儿缺血缺氧性脑病（HIE）。
方法：将2017年5月至2019年4月我院收治的HIE患儿130例，按照随机对照试验方案分为两组，每组65例。对照组给予神经节苷脂治疗,联合组用神经节苷脂+NGF治疗2周。
结果：联合组治疗总有效率(90.77%)高于对照组(76.92%)。吸吮的恢复时间，意识,联合组的肌张力和原始反射比对照组短，1年后，联合组神经系统后遗症发生率（4.62％）低于对照组（15.38％）（P<0.05）。
结论：神经节苷脂联合NGF可促进肌张力恢复，减少神经后遗症，这可能是通过修复受损的神经元细胞来实现的，增强抗氧化酶活性，促进炎症消退。
方法：将2017年5月至2019年4月我院收治的HIE患儿130例，按照随机对照试验方案分为两组，每组65例。对照组给予神经节苷脂治疗,联合组用神经节苷脂+NGF治疗2周。
结果：联合组治疗总有效率(90.77%)高于对照组(76.92%)。吸吮的恢复时间，意识,联合组的肌张力和原始反射比对照组短，1年后，联合组神经系统后遗症发生率（4.62％）低于对照组（15.38％）（P<0.05）。
结论：神经节苷脂联合NGF可促进肌张力恢复，减少神经后遗症，这可能是通过修复受损的神经元细胞来实现的，增强抗氧化酶活性，促进炎症消退。
