Abstract：
Macropinocytosis, an evolutionarily conserved endocytic mechanism that mediates non-specific fluid-phase uptake, is potently upregulated by various oncogenic pathways. It is now well appreciated that high macropinocytic activity is a hallmark of many human tumors, which use this adaptation to scavenge extracellular nutrients for fueling cell growth. In the context of the nutrient-scarce tumor microenvironment, this process provides tumor cells with metabolic flexibility. However, dependence on this scavenging mechanism also illuminates a potential metabolic vulnerability. As such, there is a great deal of interest in understanding the molecular underpinnings of macropinocytosis. In this review, we will discuss the most recent advances in characterizing macropinocytosis: the pathways that regulate it, its contribution to the metabolic fitness of cancer cells, and its therapeutic potential.
摘要：
巨噬细胞增多症,一种进化上保守的内吞机制，介导非特异性液相摄取，被各种致癌途径有效上调。现在人们很清楚，高巨噬细胞活性是许多人类肿瘤的标志，它们利用这种适应来清除细胞外营养以促进细胞生长。在营养稀缺的肿瘤微环境中，这个过程为肿瘤细胞提供了代谢的灵活性。然而,对这种清除机制的依赖也说明了潜在的代谢脆弱性。因此，人们对了解巨噬细胞增多的分子基础非常感兴趣。在这次审查中,我们将讨论最近的进展，在表征巨细胞增多症：调节它的途径，它对癌细胞代谢适应性的贡献，以及它的治疗潜力。
