PDF(Pubmed)
Abstract：
Non-gestational choriocarcinoma (NGCO) of the ovary is rare, with a prevalence of less than 0.6% of all ovarian germ-cell tumors; and when found with other germ cell tumors, pure NGCO is exceedingly rare. We herein report the case of a 22-year-old woman who complained of menstrual disorders for over 2 months. MRI examination revealed an 11.4 cm right adnexal mass of the uterus, and the patients manifested an elevated serum level of β-hCG of 77,928 mIU/ml. Fertility-preserving surgery was performed, and the pathologic diagnosis was pure NGCO; immunohistochemical staining showed cancer cells that were positive for β-hCG, CK, hPL, SALL4, and Ki-67 (>80% of cells stained). We performed polymorphic DNA analysis and non-gestational origin was confirmed. The patient was then treated with six courses of chemotherapy with a BEP regimen, after which her serum β-hCG levels declined to normal levels, and she was free of disease at the 30-month follow-up.
摘要：
卵巢的非妊娠绒毛膜癌（NGCO）很少见，所有卵巢生殖细胞肿瘤的患病率不到0.6%；当发现其他生殖细胞肿瘤时，纯NGCO是非常罕见的。我们在此报告了一名22岁女性抱怨月经失调超过2个月的病例。MRI检查显示子宫右附件肿块11.4厘米，患者血清β-hCG水平升高77,928mIU/ml。进行了保留生育力的手术，病理诊断为单纯NGCO；免疫组化染色显示癌细胞β-hCG阳性，CK,hPL,SALL4和Ki-67(>80%的细胞染色)。我们进行了多态性DNA分析，并确认了非妊娠起源。然后，患者接受了六个疗程的BEP方案化疗，之后，她的血清β-hCG水平下降到正常水平，在30个月的随访中，她没有疾病。
