Abstract：
Practical risk reduction strategies are needed to address cardiovascular disease. Beans can decrease LDL cholesterol; however, research into different daily amounts and varieties is warranted.
To examine the effects of canned beans (daily rotation of black, navy, pinto, dark red kidney, white kidney) in 1-cup (1CB, 180 g) and ½-cup (½CB, 90 g) daily amounts compared with a 1-cup white rice (WR) control on serum lipid and glycemic biomarkers in adults with elevated LDL cholesterol.
Adults [n = 73, mean ± SD age: 48.1 ± 14.2 y; BMI (in kg/m2): 25.9 ± 4.22; fasting serum LDL cholesterol: 3.0-5.0 mmol/L] consumed 1CB, ½CB, and WR for 4-wk treatment periods separated by ≥4-wk washouts in a multicenter, randomized, crossover study. Fasting serum LDL cholesterol (primary outcome) and other lipids and glycemic biomarkers (secondary outcomes) were measured on study days 1 and 29 of each treatment period with study day 29 values compared using repeated-measures ANCOVA, including study day 1 values as covariates.
Treatment completion was n = 66 for 1CB, n = 68 for ½CB, and n = 64 for WR. Total cholesterol on study day 29 was lower for 1CB (P = 0.04) but not ½CB (P = 0.77) compared with WR (-5.46%, -2.74%, -0.65% changes from study day 1, respectively) and did not differ between 1CB and ½CB (P = 0.17). LDL cholesterol on study day 29 was also lower for 1CB (P = 0.002) but not ½CB (P = 0.30) compared with WR (-8.08%, -3.84%, +0.49% changes from study day 1, respectively) and did not differ between 1CB and ½CB (P = 0.11). Other lipids and glycemic biomarkers did not differ among treatments.
Consumption of 1 cup (180 g) of canned beans of multiple varieties decreased total and LDL cholesterol in adults with elevated LDL cholesterol, supporting a practical strategy for cardiovascular disease risk reduction. This trial was registered at clinicaltrials.gov as NCT03830970.
To examine the effects of canned beans (daily rotation of black, navy, pinto, dark red kidney, white kidney) in 1-cup (1CB, 180 g) and ½-cup (½CB, 90 g) daily amounts compared with a 1-cup white rice (WR) control on serum lipid and glycemic biomarkers in adults with elevated LDL cholesterol.
Adults [n = 73, mean ± SD age: 48.1 ± 14.2 y; BMI (in kg/m2): 25.9 ± 4.22; fasting serum LDL cholesterol: 3.0-5.0 mmol/L] consumed 1CB, ½CB, and WR for 4-wk treatment periods separated by ≥4-wk washouts in a multicenter, randomized, crossover study. Fasting serum LDL cholesterol (primary outcome) and other lipids and glycemic biomarkers (secondary outcomes) were measured on study days 1 and 29 of each treatment period with study day 29 values compared using repeated-measures ANCOVA, including study day 1 values as covariates.
Treatment completion was n = 66 for 1CB, n = 68 for ½CB, and n = 64 for WR. Total cholesterol on study day 29 was lower for 1CB (P = 0.04) but not ½CB (P = 0.77) compared with WR (-5.46%, -2.74%, -0.65% changes from study day 1, respectively) and did not differ between 1CB and ½CB (P = 0.17). LDL cholesterol on study day 29 was also lower for 1CB (P = 0.002) but not ½CB (P = 0.30) compared with WR (-8.08%, -3.84%, +0.49% changes from study day 1, respectively) and did not differ between 1CB and ½CB (P = 0.11). Other lipids and glycemic biomarkers did not differ among treatments.
Consumption of 1 cup (180 g) of canned beans of multiple varieties decreased total and LDL cholesterol in adults with elevated LDL cholesterol, supporting a practical strategy for cardiovascular disease risk reduction. This trial was registered at clinicaltrials.gov as NCT03830970.
摘要：
需要切实可行的风险降低策略来解决心血管疾病。豆类可以降低LDL胆固醇;然而，有必要对不同的日用量和品种进行研究。
为了检查罐装豆类的影响（每天旋转黑色，海军,平托,深红色的肾，白肾）在1杯（1CB，180克）和½杯（½CB，90g）与1杯白米（WR）对照对LDL胆固醇升高的成年人的血清脂质和血糖生物标志物的每日量。
成人[n=73，平均±SD年龄：48.1±14.2岁；BMI（kg/m2）：25.9±4.22；空腹血清LDL胆固醇：3.0-5.0mmol/L]消耗1CB，½CB,和WR为4周治疗期，在多中心间隔≥4周冲洗，随机化，交叉研究。在每个治疗期的研究第1天和29天测量空腹血清LDL胆固醇（主要结果）和其他脂质和血糖生物标志物（次要结果），并使用重复测量ANCOVA比较研究第29天的值。包括研究第1天值作为协变量。
1CB治疗完成n=66，n=68对于½CB，对于WR，n=64。与WR（-5.46％，-2.74%，分别从研究第1天开始变化-0.65％），并且在1CB和1/2CB之间没有差异（P=0.17）。与WR（-8.08%，-3.84%，分别从研究第1天开始变化0.49％），并且在1CB和1/2CB之间没有差异（P=0.11）。其他脂质和血糖生物标志物在治疗之间没有差异。
食用1杯（180克）多个品种的罐装豆类降低LDL胆固醇升高的成年人的总胆固醇和LDL胆固醇，支持降低心血管疾病风险的实用策略。该试验在clinicaltrials.gov注册为NCT03830970。
为了检查罐装豆类的影响（每天旋转黑色，
成人[n=73，平均±SD年龄：48.1±14.2岁；BMI（kg/m2）：25.9±4.22；空腹血清LDL胆固醇：3.0-5.0mmol/L]消耗1CB，
1CB治疗完成n=66，
食用1杯（180克）多个品种的罐装豆类降低LDL胆固醇升高的成年人的总胆固醇和LDL胆固醇，
