细胞膜胆固醇的自噬激活和降低有助于非小细胞肺癌的抗癌活性。
关键词: Akt/mTOR/p70S6K pathway autophagy non-small cell lung cancer para-toluenesulfonamide plasma membrane cholesterol
Mesh : Antineoplastic Agents / pharmacology Antineoplastic Combined Chemotherapy Protocols / pharmacology Autophagy / drug effects physiology Carcinoma, Non-Small-Cell Lung / drug therapy metabolism pathology Cell Line, Tumor Cell Membrane / chemistry drug effects metabolism Cholesterol / metabolism Gefitinib / administration & dosage Humans Lung Neoplasms / drug therapy metabolism pathology Lysosomes / drug effects metabolism Proto-Oncogene Proteins c-akt / metabolism Ribosomal Protein S6 Kinases, 70-kDa / metabolism Sulfonamides / administration & dosage pharmacology TOR Serine-Threonine Kinases / metabolism Toluene / administration & dosage analogs & derivatives pharmacology
来 源:
DOI:10.3390/molecules26195967
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