PDF(Pubmed)
Abstract：
We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 February 2021. After application of the exclusion criteria, 791 papers remained. These were read and data on the chosen subjects were extracted. We found 192 papers on the effects of cordycepin on cell survival and proliferation and calculated a median inhibitory concentration (IC50) of 135 µM. Cordycepin consistently repressed cell migration (26 papers) and cellular inflammation (53 papers). Evaluation of 76 papers on signal transduction indicated consistently reduced PI3K/mTOR/AKT and ERK signalling and activation of AMPK. In contrast, the effects of cordycepin on the p38 and Jun kinases were variable, as were the effects on cell cycle arrest (53 papers), suggesting these are cell-specific responses. The examination of 150 animal studies indicated that purified cordycepin has many potential therapeutic effects, including the reduction of tumour growth (37 papers), repression of pain and inflammation (9 papers), protecting brain function (11 papers), improvement of respiratory and cardiac conditions (8 and 19 papers) and amelioration of metabolic disorders (8 papers). Nearly all these data are consistent with cordycepin mediating its therapeutic effects through activating AMPK, inhibiting PI3K/mTOR/AKT and repressing the inflammatory response. We conclude that cordycepin has excellent potential as a lead for drug development, especially for age-related diseases. In addition, we discuss the remaining issues around the mechanism of action, toxicity and biodistribution of cordycepin.
摘要：
我们对有关虫草素对细胞存活和增殖的影响的文献进行了系统的回顾，炎症,信号转导和动物模型。截至2021年2月1日的截止日期，共发现了1204种有关虫草素的出版物。应用排除标准后，仍有791篇论文。读取这些并提取所选受试者的数据。我们发现了192篇关于虫草素对细胞存活和增殖的影响的论文，并计算出135µM的中位抑制浓度（IC50）。虫草素一致抑制细胞迁移(26篇论文)和细胞炎症(53篇论文)。对76篇关于信号转导的论文的评估表明一致降低的PI3K/mTOR/AKT和ERK信号传导以及AMPK的激活。相比之下,虫草素对p38和Jun激酶的影响是可变的，对细胞周期停滞的影响(53篇论文)，表明这些是细胞特异性反应。对150例动物研究的检验表明，纯化的虫草素具有许多潜在的治疗作用，包括减少肿瘤生长（37篇论文），抑制疼痛和炎症（9篇论文），保护大脑功能（11篇论文），呼吸和心脏疾病的改善（8和19篇论文）和代谢紊乱的改善（8篇论文）。几乎所有这些数据都与虫草素通过激活AMPK介导其治疗效果一致，抑制PI3K/mTOR/AKT和抑制炎症反应。我们得出的结论是，虫草素作为药物开发的领导者具有极好的潜力，尤其是与年龄有关的疾病。此外,我们围绕作用机制讨论剩余的问题，虫草素的毒性和生物分布。
